摘要
目的:探讨Livin、血管内皮生长因子(VEGF)在甲状腺癌中的表达与临床病理因素的关系。方法:采用免疫组织化学EnVison两步法检测70例甲状腺癌、18例甲状腺瘤及18例正常甲状腺组织中Livin、VEGF的表达,并对其与性别、年龄、肿瘤大小、病理学分型、临床分期及淋巴结转移的关系进行分析。结果:70例甲状腺癌中Livin、VEGF的阳性率分别为65.7%、61.4%,与甲状腺瘤、正常甲状腺组织相比较差异有统计学意义(P<0.05)。甲状腺癌中Livin、VEGF的表达在不同病理类型、临床分期、淋巴结转移相比较差异有统计学意义(P<0.05)。经Spearman等级相关性分析表明,Livin与VEGF的表达呈正相关(r=0.484,P<0.001)。结论:Livin和VEGF的异常表达与甲状腺癌的发生发展有关,可作为甲状腺癌预后的参考指标。
Objective： To study the expressions of Livin and VEGF in thyroid carcinoma and theirs relationships with the clinicopathologic parameters, Methods： Expressions of Livin and VEGF were detected in 70 cases of thyroid carcinoma, 18 of thyroid adenoma and 18 of normal thy roid tissues by EnVison immunohistochemistry, and meanwhile, compared with sex,age, tumor size, pathology subtypes, TNM stages, and lymph node metastasis of thyroid carcinoma. Results： Livin and VEGF were expressed in 65.7% and 61.4% respectively, of the 70 cases with thyroid carcinoma, with significant difference compared with those in thyroid adenomas and normal tissues（P〈0.05）. Ex- pressions of Livin and VEGF varied with pathology subtypes,TNM stages, and lymph node metasta- sis （P〈0.05）. Significantly positive correlation was found between the expression of Livin and VEGF by using spearman correlation analysis（r=0.484, P〈0.001 ）. Conclusion： The abnormal expression of Livin and VEGF gene may promote tumor genesis and progression in thyroid carcinoma and may be used as the markers for prognosis.
出处
《中国现代普通外科进展》
CAS
2013年第4期270-273,共4页
Chinese Journal of Current Advances in General Surgery
基金
山东省滨州市科技发展计划项目(2011ZC0934)
