摘要
甲状腺结节是临床常见的内分泌系统疾病,发病率呈逐年上升趋势。甲状腺结节病理类型多样,对不典型病变的诊断仍有一定困难,可能导致误诊或漏诊。术前检查不确定和手术方式的多样性均会导致肿瘤残留率和复发率增加。近年来,随着分子生物学的发展,甲状腺相关分子标志物研究取得了很大进展。灵敏度高、特异性强的分子标志物有助于甲状腺结节的早期诊断,特别是联合检测具有较高灵敏度和特异度的分子标志物不仅能提高诊断的准确率,而且对治疗方案的制订以及预后预测均具有重要意义。
Thyroid nodule is a common clinical disease of endocrine system,the incidence of which has been rising year by year.The pathological types of thyroid nodules are varied,and the diagnosis of atypical lesions is still difficult,leading to possible misdiagnosis or missed diagnosis.The uncertainty of preoperative examination and the diversity of surgical methods will lead to the increase in tumor residual rate and recurrence rate.In recent years,with the development of molecular biology,great progress has been made in the study of thyroid related molecular markers.The molecular markers with high sensitivity and strong specificity are helpful for the early diagnosis of thyroid nodule,especially that the combination detection can not only improve the accuracy of diagnosis,but also play an important role in the formulation of the treatment plans and prognosis prediction.
作者
郭宏义
宁亚文
李文龙
赵舸
GUO Hongyi;NING Yawen;LI Wenlong;ZHAO Ge(Shanxi Medical University,Taiyuan 030001,China;Department of General Surgery,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《医学综述》
2020年第22期4515-4520,4527,共7页
Medical Recapitulate
关键词
甲状腺结节
分子标志物
检测
诊断
Thyroid nodules
Molecular markers
Detection
Diagnosis
