摘要
目的:探讨COX-2和CXCR4在膀胱癌中的表达及意义。方法:应用免疫组织化学方法检测30例膀胱癌患者CXCR4、COX-2蛋白表达,分析CXCR4和COX-2的表达与膀胱癌浸润程度的关系。结果:10例正常膀胱黏膜组织中,CXCR4、COX-2蛋白阳性表达率均为20%,30例膀胱癌组织中,其CXCR4、COX-2阳性表达率分别为77.5%、80%,P<0.01,差异有统计学意义。病变局限在黏膜层的癌组织,其CXCR4、COX-2蛋白阳性表达率分别为50%、61.1%;浸润深度达肌层组的癌组织CXCR4、COX-2蛋白阳性表达率分别为100%、95.5%,P<0.01,差异有统计学意义。经Spearman等级相关性分析表明,CXCR4和COX-2表达水平之间成正相关关系(rs=0.477,P<0.01)。结论:COX-2和CXCR4在浸润膀胱癌中均有较高表达,可以考虑作为膀胱癌早期的诊断、分析膀胱癌浸润程度的标志物。
Objective： To study the expression and relationship of CXCR4 and COX-2 in bladder carcinama.Methods： The expressions of CXCR4 and COX-2 were determined in 30 tissue specimens of bladder carcinoma by immunohistochemistry technique.Results： The positive expression rates of CXCR4 and COX-2 of control group and treatment group were 20%,20% and 77.5%,80%.CXCR4 and COX-2 expression of mucosa were 50%,61.1%,and that of muscular layer were 100%,95.5%.There was significant difference in two groups（P 0.01）.There was positive correlation between CXCR4 and COX-2 in cancer group（r s = 0.477,P 0.01）.Conclusion： The expression of CXCR4 and COX-2 may be used as new markers for early diagnosis and carcinomatous infiltration of patients with bladder carcinoma.
出处
《现代肿瘤医学》
CAS
2012年第4期771-773,共3页
Journal of Modern Oncology
