摘要
目的:检测Livin在胃癌组织中的表达,探讨其与胃癌的关系及作用机制。方法:采用RT-PCR法检测Livin mRNA在79例胃癌及30例癌旁正常组织中的表达,分析Livin表达与胃癌临床病理因素之间的关系。结果:胃癌组织中Livin mRNA表达显著高于癌旁正常组织(P<0.01);Livin mRNA表达肿瘤大小、生长方式、浸润深度、淋巴结转移、TNM分期显著性相关,差异均有统计学意义(P<0.05)。结论:Livin在胃癌的发生、发展过程中起重要作用,为胃癌的诊断及治疗提供了一个新的途径,也可成为观察疗效的新指标。
Objective To detect the expression of Livin in the tissues of gastric cancer, and explore its roles in the carcinogenesis of gastric cancer. Methods The expression of Livin mRNA in 79 cases of gastric cancer, 30 cases of adjacent tissue normal tissue were detected by using RT-PCR （reverse-transeription PCR）, and its relationship with clinical pathological features was analyzed. Results The expression of Livin mRNA in gastric cancer is much higher than in adjacent normal tissue（P 〈 0.01）. The expression of Livin mRNA was significantly related with the tumor size, growth pattern,depth of invasion,lymph-node metastasis and TNM stage （P 〈 0.05）. Conclusion The expression of Livin plays the important role in tumorigenesis of gastric cancer; may provide a newpathway with diagnosis and treatment of gastric cancer and become a new index to observe curative effect.
出处
《实用医学杂志》
CAS
北大核心
2009年第23期3921-3923,共3页
The Journal of Practical Medicine
基金
温岭市科技局基金资助项目(编号:wl20083055)
