摘要
目的 探讨庚型肝炎病毒 (HGV)感染对慢性丙型肝炎 (CH -C)的临床与病理学影响。方法 应用逆转录 -聚合酶链反应 (RT -PCR)法对 5 3例经肝穿活检确诊的CH -C患者血清标本进行了HGV -RNA检测 ,并将合并与未合并HGV感染者进行了临床与病理学对比。结果 HGV -RNA阳性 15例 (2 8 30 % )。合并与未合并HGV感染者在临床表现、肝功能等生化指标水平、HCV -RNA阳性率及肝脏病理损害等方面差异均无显著性 (p >0 0 5 )。结论 HGV感染对CH
Objective To explore the clinical and pathological effect of hepatitis G virus infection on chornic hepatitis C.Methods Detecting HGV-RNA by reverse transcription-polymerase chain reaction from serum samples of 53 chronic hepatitis C through patients as diagnosed by liver biopsy. The clinical and pathologic features of the patients with positive HGV-RNA were compared with those of patients with negative HGV-RNA.Results The results showed that 15 patients(28.3%)were positive for serum HGV-RNA and there were no significant differences in clinical manifestations,biochemical indexes,HCV-RNA positive rates and the liver pathologic lesions between these HCV RNA positive and negative groups( p >0.05).Conlusion These data indicate that HGV coinfection does not affect the liver lesions and HCV replication of chronic hepatitis C.
出处
《中华实验和临床病毒学杂志》
CSCD
2000年第3期250-252,共3页
Chinese Journal of Experimental and Clinical Virology
