摘要
目的 :探讨慢性低O2 高CO2 大鼠肺肥大细胞 (MC)对肺小动脉的作用。方法 :采用慢性低O2 高CO2 肺动脉高压模型 ,观察大鼠肺MC和肺小动脉形态改变及测定肺动脉压。结果 :观察到大鼠肺动脉压力升高和肺MC脱颗粒及空泡变。结论 :肺MC可能也是肺动脉高压形成的因素之一。
Aim: To study effects of the mast cell on the pulmonary artery in pulmonary hypertension rats induced by hypoxia and hypercapnia. Methods: In pulmonary hypertension rats induced by chronic hypoxia and hypercapnia,the MC and the PA were observed and the mPAP were measured.Results:The MC showed degranulation and vacuolar degeneration. The fibroblast showed proliferation:The mPAP were increaded.Conclusion:The MC is one of possible factor to increase pulmonary hypertension.
出处
《中国应用生理学杂志》
CAS
CSCD
2000年第3期254-256,共3页
Chinese Journal of Applied Physiology
基金
浙江省自然科学基金!资助项目 (3985 30 )
温州市科委资助!项目 (KW 96 0 0 0 5 )
