摘要
目的 了解金黄色葡萄球菌的临床分布及耐药情况,指导临床合理用药.方法 收集海军总医院2008～2011年期间临床和门诊患者样本的1 252株金黄色葡萄球菌,采用BIOMIC仪进行药敏试验,通过WHONET5.4软件分析菌株的耐药性.结果 2008～2011年海军总医院检出金黄色葡萄球菌1 252株,其中MRSA 898株,MRSA在金黄色葡萄球菌中平均发生率为71.7%,金黄色葡萄球菌检出以痰标本为主.4年间金黄色葡萄球菌对利奈唑胺和万古霉素未发现耐药株,对呋喃妥因和复方新诺明敏感性尚好,耐药率小于30%;对四环素、左氧氟沙星、克林霉素、环丙沙星、头孢唑啉、红霉素、阿齐霉素、青霉素耐药率均达50%以上,且表现为多药耐药,其中以五种耐药率最高（84.1%）,痰标本中金黄色葡萄球菌对抗生素的耐药率除利奈唑胺、万古霉素、呋喃妥因、复方新诺明外均高于总标本中金黄色葡萄球菌的耐药率.结论 MRSA耐药性高,应规范临床用药,加强MRSA耐药性监测,有效控制感染.
Objective To investigate the distribution and antimierobial resistance ot Staphylococcus aureus and cllrect antmtotics use. Methods 1 252 Staphylococcus aureus collected Navy General Hospital during the period from 2008 to 2011 in patients with clinical and outpatient samples,antibiotic sensitivity was tested by the BIOMIC,and the antimicrobial resistance data were analyzed with WHONET 5.4 software. Results 1 252 Staphylococcus aureu strains were isolated in Navy General Hospital from 2008 to 2011, including 898 MRSAs with the detective rate of 71.7%. The main sample type from the Staphylococcus aureus were detected was sputum. No LNZ and aureus presented relative sensitivity to NIT and SXT, with the VAN resistance stains were identified among 4 years. The S. resistance rate below 30%. Whereas,the resistance rates to TCY, LVX, CLX, CIP,CZO, ERY, AZM and PEN were allabove 50 % and behave multidrug resistance, Among which, five kinds of drug resistance strains possessed the majority amounts （84.1 %）. The resistance ratio to all sorts of antibiotics of S. aureus from sputum, except for LNZ, VAN, NIT and SXT, was higher than that from other types of samples. Conclusion Clinical isolates of MRSA are mostly multiple-drug resistant. Monitoring of drug resistance should be strengthened,and the antimierobial therapy should he defined on the basis of resistant pattern.
出处
《现代检验医学杂志》
CAS
2013年第1期59-62,共4页
Journal of Modern Laboratory Medicine
