摘要
目的 :自制替硝唑微型缓释药条 ,并进行药物含量测定和体内、体外释放实验 ,观察剂型的缓释效果。方法 :应用流涎冷冻法制备 ,含量测定法及溶出度测定分析技术。结果 :替硝唑缓释药条具有较好的韧性和药物缓释效果 ,满足临床治疗的要求。结论 :替硝唑微型缓释药条适用于感染根管的局部治疗。
AIM: To observe the drug delivery effect of the self-made tinidazole mini spike. METHODS: Using flowing freeze method to make tinidazole spike, and then drug content and solubility test were examined. RESULTS: This tinidazole spike had a good flexibility. It is well in drug delivery effect for control released. CONCLUSION: Tinidazole mini spike can be used in local drug delivery for the infected root canal. [
出处
《牙体牙髓牙周病学杂志》
CAS
2000年第4期217-218,共2页
Chinese Journal of Conservative Dentistry
关键词
替硝哗
流涎冰冻
缓释剂
根尖周炎
治疗
tinidazole
flowing freeze
control released delivery
periapical disease
