摘要
目的研究现阶段精神病患者乙型肝炎病毒(HBV)感染状况,为嘉兴地区乙肝防治提供依据。方法采用酶联免疫吸附试验(ELISA),对1562例住院的精神病患者进行血清HBV标志物检测。结果血清HBsAg、HBsAb、HBeAg、HBeAb、HBcAb、PreS1抗原及PreS2抗原标志物阳性率分别为6.72%、35.66%、0.96%、6.53%、18.44%、5.12%、1.54%,HBV总感染率为45.90%,PreS1抗原在HBsAg阳性的患者中阳性率73.33%(77/105);PreS2抗原在HBsAg阳性的患者中阳性率20.95%(22/105),其中男女间HBsAg阳性率差异有统计学意义(P<0.05)。结论 HBsAg阳性的精神病患者应该加强PreS1抗原及PreS2抗原的监测,对乙型肝炎病毒的早期感染和复制及患者的预后判断方面有重要价值。
Objective To study the situation of hepatitis B virus （ HBV ） infection in psychotic patients to provide a basis for hepatitis B prevention and therapy.Methods Serum samples were collected from 1 562cases of psychotic patients , and HBV markers were detected using enzyme linked immunosorbent assay （ ELISA ） .Results The detecting rates of HBsAg , HBsAb , HBeAg , Hbe- Ab , HbcAb , PreS1antigen and PreS2antigen were 6.72% , 35.66% , 0.96% , 6.53% , 18.44% , 5.12% and 1.54%.HBV infection rates were 45.90% , and the HBsAg positive rates were statistically different between men and women.Conclusion It is valuable to strengthen the targeted standard treatment for HBsAg positive psychotic patients , and targeted monitoring the PreS1and PreS2an- tigen in patients to understanding the individual infection and replication status.
出处
《国际检验医学杂志》
CAS
2012年第16期1962-1963,共2页
International Journal of Laboratory Medicine
关键词
精神病
肝炎病毒
乙型
肝炎抗原
前S蛋白质
psychotic disorders
hepatitis B virus
hepatitis antigens
pre S protein
