摘要
目的探讨CD147与PTEN及E-钙黏蛋白(E-cadherin)在食管癌组织中的表达,以期了解三者在食管癌发生、发展及转移中的意义。方法采用免疫组化法分别检测CD147、PTEN及E-cadherin在60例食管癌组织中的表达情况。结果 CD147在食管癌组织中的表达明显高于在正常食管鳞状上皮中的表达(P<0.01)。而PTEN及E-cadherin在食管癌中表达明显低于二者在正常食管组织中的表达(P<0.01)。在食管癌中CD147的表达与E-cadherin的表达呈负相关,且与浸润深度及淋巴结转移呈正相关,而CD147与PTEN表达及分化程度无明显相关。PTEN及E-cadherin的表达与淋巴结转移均呈负相关。结论 CD147、PTEN及E-cadherin共同参与食管癌的发生且影响癌细胞转移。联合检测CD147、PTEN及E-cadherin有望成为食管癌预后评估的重要生物学指标。
Objective To investigate the expressions of CD147,PTEN and E-cadherin in the esophageal carcinoma,and to explore their interactions in progression and metastasis of the esophageal carcinoma.Methods The expressions of CD147,PTEN and E-cadherin were evaluated in 60 cases with esophageal carcinoma by immunohistochemical staining methods.Results The positive rate of CD147 was significantly higher in esophageal carcinoma than that in normal squamous cell of esophagus（P0.01）.The positive rate of PTEN and of E-cadherin was significantly lower in esophageal carcinoma than that in normal squamous cell of esophagus（P0.01）.The expression of CD147 was negatively correlated with E-cadherin,and it was positively correlated with infiltration depth and the lymph-node metastasis.But the differentiating degree was not correlated with CD147 and E-cadherin.The expression of PTEN and E-cadherin were negatively correlated with the lymph-node metastasis.Conclusion CD147,PTEN and E-cadherin may play the important roles in esophageal carcinoma development and lymph node metastasis.And combined detection of CD147,PTEN and E-cadherin may be helpful in evaluation of the biological prognosis of esophageal carcinoma.
出处
《检验医学与临床》
CAS
2013年第2期129-131,共3页
Laboratory Medicine and Clinic
基金
重庆市合川区科技计划项目(201008)
