摘要
目的探讨叉头框蛋白Q1(FOXQ1)和E-钙黏蛋白(E-cadherin)在食管鳞状细胞癌(ESCC)中的表达及临床意义。方法采用免疫组织化学法检测42例ESCC组织(ESCC组)及其癌旁正常食管鳞状上皮组织(正常组)中FOXQ1和E-cadherin的表达情况,分析其表达与患者临床病理特征及预后的关系。结果 ESCC组FOXQ1的阳性表达率高于正常组(64.29%vs 28.57%,χ2=5.384,P<0.05),E-cadherin的阳性表达率低于正常组(52.38%vs 90.48%,χ2=7.691,P<0.05)。FOXQ1的表达强度在不同TNM分期及不同淋巴结转移情况间的差异有统计学意义,E-cad-herin的表达强度在不同浸润深度、分化程度、TNM分期和淋巴结转移情况间的差异有统计学意义。ESCC组织中FOXQ1和E-cadherin的表达呈负相关(r=-0.412,P<0.05)。FOXQ1高表达者的5年生存率低于低表达者(18.52%vs 66.67%,χ2=9.737,P<0.05),E-cadherin高表达者的5年生存率高于低表达者(59.09%vs 10.00%,χ2=10.996,P<0.05)。COX比例风险回归模型分析结果显示,FOXQ1高表达、E-cadherin低表达、有淋巴结转移是影响ESCC患者预后的独立危险因素。结论 FOXQ1和E-cadherin在ESCC组织中的表达呈现较好的相关性,联合检测两者的表达对于ESCC患者的预后判断及指导治疗具有一定的临床价值。
Objective To investigate the expression levels and clinical significance of（forkhead box Q1） FOXQ1 andE-cadherin in esophageal squamous cell carcinoma（ESCC）. Methods Expression levels of FOXQ1 and E-cadherin werein ESCC tissues（ESCC group, n=42） and adjacent normal esophageal tissues（control group, n=42） were detected using im-munohistochemistry. Correlations of FOXQ1 and E-cadherin expressions with clinical pathological parameters and progno-sis were analyzed between two groups. Results The expression level of FOXQ1 was significantly higher in ESCC groupthan that in control group（64.29% vs 28.57%,χ^2=5.384,P〈0.05）. The expression level of E-cadherin was significantlylower in ESCC group than that incontrol group（52.38% vs 90.48%,χ2=7.691,P〈0.05）. There were significant differencesin FOXQ1 expressions between different TNM stages and whether lymph node metastasis is involved within ESCC group.There were significant differences in expression of E-cadherin between different tumor differentiation, depth of invasion,TNM stage and whether lymph node metastasis is involved within ESCC group. The expression of FOXQ1 was negatively cor-related with E-cadherin in ESCC（r =-0.412, P〈0.05）. The 5-year survival rates were significantly lower with high expres-sion of FOXQ1 or with low expression of FOXQ1（18.52% vs 66.67%,χ^2=9.737,P〈0.05）. The 5-year survival rates weresignificantly higher with high expression of E-cadherinor low expression of E-cadherin（59.09% vs 10.00%,χ^2=10.996,P〈0.05）. A multivariate Cox＇s proportional hazard regression analysis indicated that high FOXQ1 expression, low E-cadherinexpression and lymph node metastasis were independent prognostic factors for ESCC. Conclusion The expression ofFOXQ1 and E-cadherin showed a good correlation with ESCC. And examining expressions of both FOXQ1 and E-cadherinin ESCC may have practical values in estimating the prognosis of ESCC and directing future treatment.
出处
《天津医药》
CAS
2015年第2期170-174,I0004,共6页
Tianjin Medical Journal
