摘要
通过观察肾动脉主干张开角的大小，研究了自发性高血压大鼠（Spontaneouslyhypertensiverat，SHR）高血压建立前后肾动脉零应力状态的变化，并于SHR高血压形成前，分别给予口服型AugⅡⅠ型受体拮抗剂Losartan和ETA型受体拍抗剂BMS－182874，研究内源性AugⅡ和ET在SHR肾动脉零应力状态变化中的作用。结果发现，在高血压已建立的SHR，肾动脉主干的张开角（114．2±42．2度）显著大于同龄的WKY大鼠（70．2±30．4度）。给予SHRLosartan和BMS－182874（4～16周），SHR肾动脉主干的张开角均显著减小（分别为65．9±327度和66．6±41．54度）。结果表明，在已建立高血压的SHR，肾动脉主干存在非均匀生长，其残余应力、应变大于同龄的WKY，内源性AnsⅡ和ET在SHR肾动脉零应力状态的改变中起重要作用。
By observing the opening angle of the renal artery, the zero-stress state of the renal artery was studied in spontaneously hypertensive rats (SHR) prior to and posterior to their hypertension, and the role of endogenous angiotensin Ⅱ (Ang Ⅱ ) and endothelin (ET) on the zero-stress state was studied by giving SHR Losartan(AT1 receptor antagonist of Ang Ⅱ ) and BMS-182874 (an A type receptor antagonist of ET) respectively. The opening angle of the renal artery in SHR with established hypertension was much greater than that in wistar-Kyoto rats(WKY) (114. 2±42. 2 vs 70. 2±30. 4, P＜0. 01). The opening angles of the renal artery in SHR treated with Losartan and BMS-182874 were much smaller than those in control SHR. The opening angles of the renal artery in Losartan-treated and BMS-182874-treated SHR were 65. 9 ± 32. 7 and 66. 6±41. 54 respectively.The results suggest that non-unequal growth exists in the renal arterial wall in SHR with established hypertension and the residual stress and strain in SHR are greater than those in age-matched WKY. Endogenous Ang Ⅱ and ET may play a role in the changes of zero-stress state in SHR with hypertension.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2000年第2期241-243,共3页
Journal of Biomedical Engineering
基金
国家自然科学基金!19672072
关键词
肾动脉
零应力状态
自发性高血压
大鼠
Renal artery Zero-stress state Spontaneously hypertensive rat
