摘要
选取自发性高血压大鼠 SHR在高血压形成前后的不同时相点 ,采用组织形态学方法结合计算机图像分析 ,对 SHR大鼠胸主动脉几何形态及纤维结构进行了形态定量学研究 ,测定了 SHR胸主动脉零应力状态张开角的变化及压力 -直径关系。结果表明 ,随着血压增高 ,SHR主动脉几何形态及各种显微结构指标均显著增大 ;高血压形成和发展阶段 ,SHR主动脉零应力状态张开角增大 ;高血压主动脉结构重建例如管壁增厚 ,胶原纤维不成比例地增加可能导致主动脉可扩张性降低 ;
Morphometry and microstructure of thoracic aorta of spontaneously hypertensive rats (SHR) at different periods before and after hypertension were studied quantitatively by histological method and computer image analysis. We also observed the changes of opening angle in the zero stress state and the relationship between pressure and diameter in SHR during established hypertension. The results showed that with blood pressure chronically increasing, there was a significant increase in morphometric parameters and microstructure parameters of the thoracic aorta in SHR. The zero stress state of opening angle in SHR during established hypertension increased significantly. These reults suggest that aortic structural remodeling in hypertension such as thickness of vascular wall and disproportional increase of collagen may lead to decrease in distensibility of the aorta in SHR. The structural remodeling and changes of mechanical properties in aorta may contribute to the important pathophysiology of hypertension induced complications.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2000年第1期66-70,共5页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目!(39672072)
