摘要
目的 探讨血管紧张素Ⅱ ,Ⅰ型受体拮抗剂 (AT1)对四氯化碳 (CCl4)诱导的肝硬化大鼠血流动力学的影响。方法 大鼠肝硬化模型由CCl4 诱导 ,41只雄性SD大鼠被随机分为 4组 :对照组 10、模型组 11、及治疗组 2 0 (早期 10、中期 10 ) ,除对照组外所有大鼠均给予 50 %CCl4 灌胃 ,3ml/kg/5天一次 ,共 9周。治疗组 :早期组同时血管紧张素受体拮抗剂灌胃 ,中期组于造模中期 ( 5周 )开始给药 ,用量 10mg/kg/d至处死前。实验结束时 ,苯巴比妥麻醉下开腹分别测量平均动脉压(MAP)、门静脉压 (PP)、门静脉流量 (PVF)、流速 (V )、门静脉宽度 (D)。结果 与模型组相比 ,血管紧张素受体拮抗剂可显著降低肝硬化大鼠门脉压力、血流量、流速 ,对血压有轻微的降低作用。结论 血管紧张素受体拮抗剂可降低肝硬化大鼠门静脉压力 。
Objective To assess the effects of angiotensin Ⅱ receptor antagonist losartan on portal and systemic hemodynamics in rats with cirrhosis induced by CCl 4. Methods A total of 41 rats were randomized into 4 groups: 1) control group (n=10);2) model group (n=11);3) early stage treatment group (n=10);4) middle stage treatment group (n=10). The rats in the latter 3 groups were inflicted with liver cirrhosis by oral administration of CCl 4 (50%, 3ml/kg) once per 5 days for 9 weeks. For those rats in the early stage treatment group, daily intragastric administration of losartan (10 mg·kg 1 ·d 1 ) for 9 weeks. In the middle stage treatment group, the same administration was started five weeks after the protocol began. At the end of treatment, all animals were anesthetized with Phenobarbital (50 mg·kg 1 ) and middle abdominal incision was made in all the rats. Portal pressure, mean arterial pressure and flow, flow velocity and width of the portal vein were measured. Results The portal pressure, portal vein flow and portal vein velocity were significantly decreased by the angiotension II receptor angtagonist losartan. Meanwhile, the mean arterial pressure was slightly reduced by it. Conclusions The angiotensin II receptor antagonis can ameliorate the portal hemodynamics in rats with cirrhosis and portal hypertension.
出处
《中华肝胆外科杂志》
CAS
CSCD
2003年第8期473-474,共2页
Chinese Journal of Hepatobiliary Surgery
