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口腔癌肿瘤微血管密度的研究 被引量：1

Study on intratumoral microvascular density in oral cancer
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摘要 目的　探讨口腔癌肿瘤微血管密度 (MVD)改变在口腔癌发生发展中的作用。方法　对 60例口腔癌的组织切片采用抗CD3 4单抗进行免疫组织化学染色 ,计取肿瘤MVD。结果　TNM临床分期Ⅲ ,Ⅳ期病例的MVD明显高于Ⅰ ,Ⅱ期病例 ;肿瘤细胞分化程度高的病例MVD明显高于中低分化病例 ;有淋巴结转移病例的MVD明显高于无淋巴结转移病例。结论　MVD的检测可作为反映口腔癌生物学行为的指标之一 ,测定MVD对临床具有一定的实用价值。 Objective To investigate intratumoral microvascular density (MVD) in oral cancer. Methods\ A total of 60 specimens resected from patients with oral squamous cell carcinoma were stained with monoclonal antibodies against CD 34 . Microvessel count was determined. Results\ MVD was correlated with lymph node metastasis, differentiation situation and clinical stage (P<0.05). Conclusion\ Determination on MVD can be used as an index in reflecting biological behavior of oral cancer and prognosis.
作者 徐平平 陈江 申晓青
机构地区 广东省口腔医院 福建医科大学口腔医院 第一军医大学珠江医院
出处 《广东医学》 CAS CSCD 2000年第7期554-555,共2页 Guangdong Medical Journal
关键词 口腔肿瘤 微血管密度 免疫组织化学 MVD Mouth neoplasms Intratumoral microvascular density Immunohistochemistry Metastasis
分类号 R739.802 [医药卫生—肿瘤]
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  • 1Dr. Theodore J. Saclarides M.D.,Nicholas J. Speziale M.D.,Elizabeth Drab B.S.,Debra J. Szeluga M.D., Ph.D.,David B. Rubin M.D.. Tumor angiogenesis and rectal carcinoma[J] 1994,Diseases of the Colon &amp; Rectum(9):921～926
  • 2Philip E. Thorpe,Francis J. Burrows. Antibody-directed targeting of the vasculature of solid tumors[J] 1995,Breast Cancer Research and Treatment(2):237～251

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广东医学
2000年 第7期

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