摘要
用免疫组化ＡＢＣ法对５７例口腔鳞癌进行检测，以探讨癌巢基底膜表达分布与临床病理特征及癌颈淋巴结转移之间的关系。结果表明：口腔鳞癌癌巢基底膜出现不同程度的破坏缺损，甚至完全消失，基底膜缺损与肿瘤分化和癌颈洒巴结转移密切相关（Ｐ＜０．０５）。提示口腔鳞癌基底膜表达程度对评价肿瘤分化和肿瘤浸润及转移具有重要价值。
Fifty seven cases of oral squamous cell carcinoma (SCC) were studied by immunohistochemical ABC method using type Ⅳ collagen and laminin antibody to investigate the relationship between expression and distribution of basement membrane in oral SCC and clinicopathologic characteristics and cervical lymph node metastasis. The distribution of basement membrane of oral SCC was discontinuous and in some cases the membranes disappeared. There was highly significant correlation between the staining patterns together with histologic differentiation degrees and cervical lymph node metastasis ( P <0.05). These indicate that the expression of baasement membrane in oral SCC may be a useful parameter for evaluation of tumor histologic differentiation and tumor invasion and metastasis.
出处
《湖南医科大学学报》
CSCD
1997年第1期41-44,共4页
Bulletin of Hunan Medical University
关键词
口腔肿瘤
癌磷状细胞
免疫组织化学
肿瘤转移
mouth neoplasms
carcinoma, squamous cell
immunohistochemistry
collagen
laminin
basement membrane
neoplasm metastasis
