摘要
目的 研究大肠癌组织与转移瘤的血管生成情况及其与肿瘤转移和预后的关系。方法 应用免疫组化法 ,研究了 15例有淋巴结和肝转移的大肠癌、2 0例无转移的大肠癌和正常结肠粘膜的石蜡包埋组织的微血管计数。结果 平均血管密度 (MVD )值大肠癌组织 (5 6 17± 8 31)和肝转移瘤 (94 2 6± 10 46 )明显高于正常粘膜 (2 1 36± 5 2 0 ) (P均 <0 .0 1) ,发生转移的大肠癌组织的MVD值 (90 2 7± 7 16 )明显高于未发生转移的大肠癌组织 (5 6 17± 8 31)(P <0 .0 1)。
Objective To study the angiogenesis of colorectal tumors and the metastasis, and the relationsthip between microvessel with metastasis. Methods 15 colorectal tumors with lymph node and liver metastasis, 20 colorectal tumors without metastasis, and 20 nomal mucosa were studied imunohistochemically for microvessels quantitation. Results The mean vascular density (MVD) in colorectal tumors (56.17±8.31) and liver metastasis (94.26±10.46) were significantly higher than that in nomal mucosa (21.36±5.20)(P<0.01), the MVD in colorectal with metastas (90.27±7.16) were significantly higher than that in colorectal without metastasis (51.67±8.31) (P<0.01). Conclusions MVD can be used to evaluat the metastasis and as a prognostic factor in colorectal cancer patients.
出处
《中国普通外科杂志》
CAS
CSCD
2001年第3期241-243,共3页
China Journal of General Surgery
