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多环氧杂蒽酮类抗生素研究进展 被引量：4

Research progresses of polycyclic xanthone antibiotics
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摘要 多环氧杂蒽酮类抗生素是一类由微生物II型聚酮合成酶合成的重要抗生素,普遍具有抗细菌、真菌和抗肿瘤等活性。本文对这一家族中具有代表性的抗生素的结构、生物活性进行了总结,并介绍了lysolipin等4种抗生素的生物合成研究进展。 Polycyclic xanthone antibiotics, with the activities of antibacterial, antifungal and anticancer et al, are biosynthesized by type II polyketides synthase of microorganism. Structures and biological activities of the typical members of this antibiotics family were described, and the biosynthetic finding on 4 members, including lysolipins, were also reviewed.
作者 李力 黄建忠
机构地区 福建师范大学工业微生物教育部工程研究中心
出处 《中国抗生素杂志》 CAS CSCD 北大核心 2012年第11期806-812,共7页 Chinese Journal of Antibiotics
基金 国家自然科学基金(31000038) 福建省自然科学基金(2010J05057) 福建省教育厅科技项目(JA09062)资助
关键词 多环氧杂蒽酮 抗生素 化学结构 生物活性 生物合成 Polycyclic xanthone Antibiotics Chemical structure Biological activity Biosynthesis
分类号 R978.1 [医药卫生—药品]
  • 相关文献

参考文献42

  • 1Hertweck C. The Biosynthetic Logic of Polyketide Diversity [J]. Angew Chem lnt Ed, 2009, 48(26): 4688-4716.
  • 2陈祈磊,赵子翰,王辂,褚以文.黄灰链霉菌SIIA-A02191产生的多环口山酮类新抗生素Bromoxantholipin(英文)[J].中国抗生素杂志,2011,36(8):566-570. 被引量：3
  • 3Lopez P, Hornung A, Welzel K, et al. Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042 [J]. Gene, 2010, 461(1-2): 5-14.
  • 4Solov'Eva N K, Rudaia S M. Characteristics of the organism producing a new antifungal antibiotic albofungin [J]. Antibiotiki, 1959, 4: 5-10.
  • 5Gurevich A I, Karapetyan M G, Kolosov M N, et al. The structure of albofungin[J]. Tetrahedron Lett, 1972, 13(18): 1751-1754.
  • 6Fukushima K, Ishiwata K, Kuroda S, et al. Identity of antibiotic P-42-1 elaborated by Actinomyces tumemacerans with kanchanomycin and albofimgin[J]. J Antibiot (Tokyo), 1973, 26(2): 65-69.
  • 7Bateman J R, Marsh A A, Steinfeld J L. Kanchanomycin (Nsc-62773): A Phase I. Study[J]. Cancer Chemother Rep, 1965, 44: 25-26.
  • 8Drautz H, Keller-Schiertein W, Zahner H. Metabolic products of microorganisms, 149. Lysolipin I, a new antibiotic from Streptomyces violaceoniger (author's transl) [J]. Arch Microbiol, 1975, 106(3): 175-190.
  • 9Dobler M, Keller-Schierlein W. Metabolites of microorganisms. 162nd Communication. The crystal and molecular structure of lysolipin I [J]. Helv Chim Acta, 1977, 60(1): 178-185.
  • 10Omura S, Iwai Y, Hinotozawa K, et al. Cervinomycin A1 and A2, new antibiotics active against anaerobes, producedby Streptomyces cervinus sp. Nov[J]. J Antibiot (Tokyo), 1982, 35(6): 645-652.

二级参考文献42

  • 1Hopwood D A. Genetic contributions to understanding polyketide synthases [J]. Chem Rev, 1997,97 (7): 2465.
  • 2Bailey J E, Birnbaum S, Galazzo J L, et al. Strategies and challenges in metabolic engineering [J]. Ann NY Acad Sci, 1990,589: 1.
  • 3Malpartida F, Hopwood D A. Molecular cloning of the whole biosynthetic pathway of a Streptom,yces antibiotic and its expression in a heterologous host [J]. Nature,1984,309(5967):462.
  • 4Malpartida F, Hallam S E, Kieser H M, et al. Homology between Streptomyces genes coding for synthesis of different polyketides used to clone antibiotic biosynthetic genes [J]. Nature,1987,325(6107):818.
  • 5Cortes J, Haydock S F, Roberts G A, et al. An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea [J]. Nature,1990,348(6297): 176.
  • 6Donadio S, Stayer M J, McAlpine J B, et al. Modular organization of genes required for complex polyketide biosynthesis [J]. Science, 1991,252 (5006): 675.
  • 7I Chater K F. The improving prospects for yield increase by genetic engineering in antibiotic-producing Streptomycetes [J]. Biotechnology (N Y), 1990,8(2): 115.
  • 8Kim C G, Yu T W, Fryhle C B, et al. 3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics [J]. J Biol Chem, 1998,273(11): 6030.
  • 9Stratmann A, Mahmud T, Lee S, et al. The AebC protein from Actinoplanes species is a CT-eyelitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor aearbose [J]. J Biol Chem,1999,274(16):10889.
  • 10Piel J, Hertweck C, Shipley P R, et al. Cloning,sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase [J]. Chem Biol,2000,7(12):943.

共引文献42

同被引文献42

  • 1Chun-hui YANG,Li MA,Zhen-ping WEI,Feng HAN,Jing GAO.Advances in Isolation and Synthesis of Xanthone Derivatives[J].Chinese Herbal Medicines,2012,4(2):87-102. 被引量：3
  • 2黄金莲,应福余,胡苏球,施梅芳.环丙沙星的耐药性变迁分析[J].现代预防医学,2005,32(1):80-82. 被引量：6
  • 3王妍,韩燕星,蒋建东.刺孢霉素族抗生素的研究进展[J].中国新药杂志,2007,16(17):1341-1345. 被引量：4
  • 4Kunimoto, S., Lu, J., Esumi, H., et al.Kigamicins, Novel Antitumor [J].The Journal of Antibiotics,2003,56(12):1 004-1 011.
  • 5Wright, L.& Hopwood, D.Actinorhodin is a chromosomally-deter- mined antibiotic in Streptomyces coelicolor A3(2)[J].J.Gen.Mi- crobiol, 1976,96: 289-297.
  • 6Johnson, L.E.& Dietz, A.Kalafungin, a new antibiotic produced by Streptomyces tanashiensis strain Kala[J].Applied Microbiology, 1968,16:1 815-1 821.
  • 7Donner, C.D.Total synthesis of (+)-kalafungin using a tandem Michael - Dieckmann approach[J].Tetrahedron Lett, 2007, 48:8 888-8 890.
  • 8Fitzgerald, J.T., Ridley, C.P.& Khosla, C.Engineered biosynthesis of the antiparasitic agent frenolicin B and rationally designed analogs in a heterologous host[J].The Journal of Antibiotics, 2011,64 : 759-762.
  • 9Takano,S.,Hasuda,K.,Ito,A.,Koide,Y,et al.A new antibiotic,me- dermycin[J].The Journal of Antibiotics,1976,29:765.
  • 10Ichinose,K.,Ozawa,M.,Itou,K.,et al.Cloning,sequencing and het- erologous expression of the medermycin biosynthetic gene clus- ter of Streptomyees sp.AM-7161: towards comparative analysis of the gene clusters[J].Microbiology,2003,149:1 633-1 645.

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中国抗生素杂志
2012年 第11期

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