摘要
鉴于芳香聚酮化合物在抗菌、抗肿瘤、抗病毒等方面具有重要的临床药用价值,该文综述了细菌芳香聚酮化合物及其生物合成研究的主要进展,重点讨论了四类芳香聚酮的生物活性和化学结构以及芳香聚酮生物合成机理研究的基础理论意义。在此基础上对组合生物合成新的具有一定生物活性化合物的研究前景进行了展望。
This article provides a research progress of aromatic polyketide and its biosynthetic logic in hght ot its significant application pharmaceutically and clinically as noteworthy antieancer, antibacterial, antifungal and antivi ral substances, with the emphasis on the discussion of four classes of aromatic compounds in bioactivity and chemical structure as well as several fundamental insights on the biosynthetic mechanism.By means of a deeper understanding of the biosynthetic process, it is proposed that combinatorial biosynthesis affords a number of new avenues for creating novel molecular structures that will likely have new biological activity.
出处
《安徽农学通报》
2013年第23期8-10,共3页
Anhui Agricultural Science Bulletin
基金
国家自然科学基金(31000038)
关键词
聚酮合酶
芳香聚酮
化学结构
生物活性
生物合成
PKS
Aromatic palyketides
Chemical structure
Biological activity
Biosynthesi
