摘要
目的建立稳态流体模型,验证3.0TMR快速电影相位对比(Fast Cinephase Contrast,FastCine-PC)成像进行脑脊液流体动力学测量的准确性,同时优化成像参数。方法将直径为3.0mm的医用塑料输液管固定在水模中,塑料管的一端连接高压注射器,另一端连接容器。高压注射器以预设的不同流速向塑料管内注射0.9%氯化钠溶液。将流体模型中心置于标准头部8通道线圈中心,塑料管长轴与流体长轴一致。应用3.0T高场强MR扫描仪进行FastCINEPC序列扫描,扫描层面垂直于管腔长轴。在不同流速、不同流速编码(Velocity Encoding,VENC)、不同流动方向、不同倾斜角度情况下分别测量流速。然后对结果进行统计学分析。结果当流体流速在1.41～12.74cm/s(接近人体脑脊液流速范围),流速编码置于20cm/s时所测得流速与真实流速最接近,差异无统计学意义(P>0.05);液体流动方向与流速编码方向相同、方向相反测得的流速二者之间差异无统计学意义(P>0.05);流体管腔给予不同角度后测得的各流速值之间差异无统计学意义(P>0.05)。结论 3.0TMR快速电影相位对比序列可以准确定量测量稳态流体模型流速,为人体脑脊液动力学的研究提供可靠的实验依据。
Objective To set up a steady fluid flow phantom to verify the accuracy of 3.0T magnetic resonance imaging （MRI） fast cine phase contrast （fast cine-PC ）in measuring cerebrospinal fluid （CSF） hydrokinetics, and to optimize the imaging parameters. Methods A plastic tube with diameter being 3.0 mm was fixed in a water phantom, and one end of the tube was connected to the high pressure injector for injecting physiological saline at different velocity, however, the other one was inserted into a container. The phantom was placed in the center of a 8-channel array head coil. The tube was parallelly placed with the major axis of magnet. By means of 3.0T high field MR fast cine-PC, scanning plane was perpendicular to the major axis of tube. The different velocity with different velocity encoding （ VENC ）, in different direction of flow, at different angles was measured. Finally, the experimental results were statistically analyzed. Results When the physiological saline flow velocity was from 1.41cm/s to 12.74 cm/s and the velocity encoding was 20cm/s, there was no significant difference between the measured velocity and actual velocity（ P 〉 0.05 ） , and there was no significant difference in the measured velocity in different flow direction of liquid whether the direction was identical with VENC or opposite to VENC （ P 〉 0.05 ）. There was no significant difference in the measured velocity at different angles （ P 〉 0.05 ）. Conclusion 3.0T MR fast cine-PC is more accurate in the measurement of velocity of steady fluid flow phantom, and can provide reliable experimental basis for the study on human CSF hydrokinetics.
出处
《河北医药》
CAS
2012年第22期3382-3385,共4页
Hebei Medical Journal
关键词
磁共振成像
电影相位对比
脑脊液
magnetic resonance imaging
cine phase contrast
cerebrospinal fluid
