摘要
基于对脑部生理结构的分析,将脑部分为白质、灰质、脑脊液、颅骨和头皮5层,建立了三维脑部传热模型.讨论了外部冷量,血液灌注率和代谢产热率对温度分布的影响,研究各关键参数对脑部温度的影响规律.并着重比较了考虑脑脊液层与未考虑脑脊液层时的温度分布.结果表明,外部施加的冷量值和血液灌注率对温度分布有较大影响;在未考虑脑脊液层和考虑脑脊液层两种情况下,头皮、颅骨、脑脊液和部分灰质层的温度有较大差异.当冷量值增大时,此温差也会增大.并且两种情况下温差的峰值出现在脑脊液层.
Based on the analysis of physiological structure of the head, the three-dimension heat transfer model has been established, which is divided into five layers including the white matter, gray matter, cerebrospinal fluid, bone, and scalp. The effects of the external cold flow, blood perfusion rate, and metabolic heat generation rate on temperature distributions have been analyzed. Moreover, the effect of the cerebrospinal fluid on the temperature distribution is focused. The results show that the cold flow and blood perfusion have significant effects on the temperature distributions. The temperature-dropping zones become larger and deeper when the external cold flow and blood perfusion rate increase. However, the effect of the metabolic heat generation rate can be almost neglected. There are large differences in the temperature distributions of the scalp, bone, cerebrospinal fluid and partial gray matter between the cases, in which the effect of the cerebrospinal fluid is involved or not. These temperature differences increase when the external cold flow rises, and the largest temperature difference shows in the cerebrospinal fluid layer. The analysis and calculation results are of great importance in the practical clinic applications.
出处
《应用基础与工程科学学报》
EI
CSCD
2010年第3期484-492,共9页
Journal of Basic Science and Engineering
基金
国家自然科学基金资助项目(50976013)
关键词
生物传热
脑脊液
亚低温
局部脑冷却
温度分布
bioheat transfer
cerebrospinal fluid
hypothermia
local cerebral cooling
temperature distribution
