摘要
通过对肺水通道蛋白（aquaporins，AQPs）的结构、分布及功能的研究，发现AQPs与支气管哮喘（简称哮喘）之间存在密切关系，其中，AQP1参与了肺部水的转运、哮喘急性炎症期的发病机制，AQP3可能在保持气道表面的液体平衡及防止细菌入侵、气道重塑等方面起着重要的作用，AQP4可能参与了哮喘条件下黏液分泌的调控，AQP5则与气道高反应性、气流受限、调节气道水稳态有关，这些为哮喘的诊断及治疗开辟了新的思路。
By the researches of Lung Aquaporins＇ structure, distribution and ~unction, it is discovered that Lung Aquaporins are closely associated with bronchial asthma, among of them, AQP1 participates in the transportation of the lung water and the pathogenesis of asthma＇ acute inflammatory period; AQP3 may play an important part in keeping the water balance of the air passager surface, and preventing the invading of bacteria, remodeling of air passage; AQP4 may participates in the regulation of mucus secreting under asthma; AQP5 is connected with airway hyperreactivity, airflow limitation, and airway water balance regulation, all of these open up new ideas of asthma diagnosis and treatment.
出处
《国际呼吸杂志》
2012年第20期1570-1574,共5页
International Journal of Respiration
