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缺氧诱导因子-1在肿瘤临床方面的研究进展 被引量:2

Advances in hypoxia-inducible factor 1 in clinical research
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摘要 缺氧诱导因子 1(HIF 1)是介导缺氧适应性反应的转录因子 ,其活性的调节受多种因素的影响 ,其表达与肿瘤的生长、浸润、转移和预后等密切相关 ,并对肿瘤的治疗具有重要意义。现就其在肿瘤临床方面的研究进展进行综述。
作者 姜颖 张海青
出处 《国外医学(肿瘤学分册)》 2004年第11期829-832,共4页 Foreign Medical Sciences (Cancer Section)
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  • 1Zhong H, DeMarzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases [J]. Cancer Res,1999,59(22):5830-5835.
  • 2Bos R, Zhong H, Hanrahan CF et al. Levels of hypoxia-inducible facter-1 a during breast carcinogensis [J]. Natl Cancer Inst 2000,93:309-313.
  • 3Volm M, Koomagi R. Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer [J]. Anticancer Res,2000,20(3A):1527-1533.
  • 4Birner P, Schindl M, Obermair A, et al. Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer [J]. Cancer Res, 2000,60:4693-4696.
  • 5An WG, Kanekal M, Simon MC, et al. Stabilization of wild-type p53 by hypoxia-inducible facter1alpha [J]. Nature,1998;392:405-408.
  • 6Carmeliet P, Dor Y, Herbert JM, et al. Role of HIF-1 alpha in hypoxia-mediated apoptosis,cell proliferation and tumor angiogenesis [J]. Nature, 1998,394:485-490.
  • 7Harldar S, Negrini M, Monne M, et al. Down-regulation of bcl-2 by p53 in breast cancer cells [J]. Cancer Res,1994,54:2095-2097.
  • 8Miyashita T, Reed JC. Tumor suppressor p53 is director transcriptional activator of the human bax gene [J]. Cell,1995,80:293-299.
  • 9Bruick RK. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia [J]. Proc Natl Acad Sci USA, 2000,97(16):9082-9087.
  • 10Zhong H, Demarzo A, Semenza GL, et al. Identification of hypoxia inducible factor-1 a protein in common human cancers [J]. Proc Am Ass Cancer Res,1999,40:329.

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