摘要
Michaelis—Menten消除动力学(下称米氏型消除)是非线性药物动力学中的重要部分。大量临床研究表明,呈药动学非线性特征的药物,尤有必要进行血药浓度监测。
For intravenous injection in Michaelis-Menten elimination kinetics, the equations of maximal plasma, minimal plasma concentration and average one at steady-state were derived. It is shown that the Wagner' equation for average plasma concentration at steady-state is an approximated one. A dosing regimen is given for clinical pharmacy.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1990年第4期232-233,共2页
Journal of China Pharmaceutical University
关键词
米氏型消除
消除动力学
稳态血药浓度
Michaelis-Menten elimination kinatics
Bolos intravenous administration
Drug plasma concentration at steady-state
Dosing regimen
