摘要
目的 :观察吸入肝素对致敏豚鼠血、肺组织组胺含量的影响。方法 :以卵蛋白作为抗原 ,激发豚鼠形成哮喘豚鼠模型 ,随机分成致敏组 (A组 )、给药组 (B组 )和对照组 (C组 ) ,在卵蛋白雾化吸入后 3 0min、17h测定血、肺组织组胺浓度。结果 :致敏豚鼠吸入肝素后 ,再次接触抗原可抑制血、肺组织组胺浓度升高。结论
Objective The experiment was designed to research the effects of inhaled heparin on the the histamine concentration in lung tissue and blood of sensitized guinea pigs sensitized and challenged by ovalbumin.Method Sixty guinea pig models of asthma induced by ovalbumin were randomly allocated into three groups:sensitized,treated and control groups.The histamine concentration in lung tissue and blood of the guinea pigs was detected at 30 min and 17 h after inhalation of heparin.Result The histamine concentration in lung tissue and blood of the sensitized guinea pigs was decreased after inhaled heparin.Conclusion Heparin may play an inhibitory role in the histamine release by mast cells.
出处
《南京铁道医学院学报》
2000年第2期107-108,共2页
Journal of Nanjing Railway Medical College
关键词
肝素
组胺
豚鼠
药理
heparin
histamine
guinea pigs
