摘要
目的:建立川芎嗪自乳化缓释固体分散体释放度测定方法。方法:采用HPLC法测定川芎嗪自乳化缓释固体分散体中TMP的含量,考察相关因素对其体外释药的影响。结果:以转篮法为溶出度测定方法,释放介质为脱气纯水,转速为50r/min。结论:建立了良好的川芎嗪自乳化缓释固体分散体释放度测定方法,为评价和控制该药的质量提供依据。
Objective ： To establish release rate determination methods of TMP self-emulsifying release solid dispersion. Methods ： HPLC was applied to determine the content of TMP, and different effects on release rate of TMP self-emulsifying release solid dispersion were studied in vitro. Results ： The release medium was degassed pure water, the rotation speed was 50r .min^-1. Conclusion： A good method to determine release rate of TMP self-emulsifying release solid dispersion was established, providing a basis to evaluate and control the quality of drugs.
出处
《辽宁中医药大学学报》
CAS
2012年第10期103-105,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
广东省科技计划项目(2010B030700039)
关键词
川芎嗪
自乳化缓释固体分散体
释放度
TMP
self-emulsifying release solid dispersion
release rate
