摘要
目的:制备长春西汀自乳化固体分散体,并测定其体外特性。方法:以自乳化辅料和泊洛沙姆188(F68)为载体制备长春西汀自乳化固体分散体,考察不同自乳化辅料及用量、不同制备方法、投药量和溶出介质对自乳化固体分散体溶出特性的影响,并采用差热分析、X-射线粉末衍射分析鉴别药物在载体中的存在状态。结果:与普通固体分散体(F1)相比,自乳化固体分散体(F8)的溶出度显著提高,药物主要以分子状态存在;自乳化辅料的种类、用量的不同对药物溶出有显著差异;溶剂法和溶剂熔融法好于熔融法;投药量和介质的不同对溶出也有一定影响。结论:与普通固体分散体相比,自乳化固体分散体能进一步提高长春西汀的溶解度和溶出度。
Objective： To prepare vinpocetine self-emulsifying solid dispersion （VIP-SESD） and determine its characteristics in vitro. Method： Seff-emulsifying solid dispersion of vinpocetine was prepared with 1768 and seff-emulsifying excipients. The dissolution in vitro were also studied, considering the effects of different self-emulsifying excipients, preparation methods, given drug content and differ- ent dissolution medias. Differential thermal analysis and powder X-ray diffraction were used to determine the status of drug in carriers. Result： Comparing with the ordinary solid dispersion （F1）, the dissolution in vitro of VIP-SESD （F8） was apparently improved, and drug in VIP-SESD （F8） almost existed as molecule. The dissolution of VIP-SESD was influenced by different self-emulsifying excipi- ents. The dissolution of VIP-SESD prepared by solvent method and solvent-melting method were better than melting method. The given drug content and different dissolution medias also had effects on the dissolution. Conclusion： Compared with the ordinary solid dispersion, the self-emulsifying solid dispersion can further improve the solubility and dissolution of vinpocetine.
出处
《中国药师》
CAS
2010年第6期776-780,共5页
China Pharmacist
基金
湖北省自然科学基金计划重点项目(编号:2008CDA062)
关键词
长春西汀
固体分散体
自乳化
溶出度
Vinpocetine
Solid dispersion
Self-emulsifying
Dissolution
