摘要
应用聚乙二醇(PEG)6000(2)和号丙烯酸树脂(3)为混和载体,用溶剂法制备了盐酸尼卡地平(1)肠溶缓释固体分散体。差热分析和X射线粉末衍射证实药物以分子状态分散于载体中。药物的释放速度受药物和载体3的比例、载体中2的含量、固体分散体粒子的大小、溶出介质的影响。稳定性实验表明,固体分散体贮存3个月后,溶出速度略有下降,药物的分散状态没有明显改变。
Nicardipine hydrochloride (1) intestinal dissolved sustained release solid dispersion was developed using PEG6000 (2) and acrylic resin Ⅱ(3) as mixed carrier by the solvent evaporating method. The DTA and X ray powder diffractometry showed that 1 molecules were dispersed in the solid dispersion. The release rate was related to the drug/carrier 3 ratio, the percentage of PEG6000 in the carrier, the granules size of solid dispersion and dissolution medium. Stability test showed that the release rate got a little slower after storage over 3 months, but the drug dispersion state didn't change significantly.\;
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2000年第3期107-110,共4页
Chinese Journal of Pharmaceuticals
关键词
盐酸尼卡地平
固体分散体
体外溶出
缓释剂
nicardipine hydrochloride
enteric material
solid dispersion
dissolution
