摘要
目的:研究长春西汀自微乳化释药系统(VIN-SMEDDS)的体外释药特性。方法:进行了体外释放度实验,考察释放度实验方法学、释放介质、转速和制剂因素对药物释放特性的影响。结果:释放度实验方法学、释放介质、转速和制剂处方因素都会对药物释放测定结果造成影响。采用反相透析技术能较好地模拟口服后的体内生理情况,在人工肠液中,转速50r·min^(-1)下,VIN-SMEDDS 累积释放百分率3h 达到68.45%。SMEDDS 制剂的电性对释放基本无影响,VIN-SMEDDS 的体外释放比长春西汀自乳化释药系统(VIN-SEDDS)好。结论:长春西汀自乳化释药系统显著提高了药物的释放速度和程度。体外反相透析释放实验的透膜限速过程属于被动扩散过程。
Objective： To study the release characters of Vinpocetine self- microemulsifying drug delivery system （VIN-SMEDDS） in vitro. Method： The dissolution of VIN-SMEDDS were determined in vitro. And the effects of different dissolution methods, dissolution media, rotational speeds and preparations on release characters of drug were studied. Result： The release characters of drug were influenced by different dissolution methods, media, rotational speeds and preparations in vitro. The reverse dialysis bag technique could preferably simulate the situation of oral drug. The cumulative dissolution ratio of VIN-SMEDDS at 3 h in pH 6.8 PBS under 50 r · min^- 1reached 68.45%. And the potention of SMEDDS almost had no effects on the dissolution tests. The cumulative dissolution ratio of VIN from SMEDDS was higher than that from SMEDDS. Conclusion： The formulation of VIN-SMEDDS can significantly improve the dissolution of vinpocetine. The process of the drug penetrating membrane with reverse dialysis technique fits passive diffusion.
出处
《中国药师》
CAS
2006年第12期1092-1095,共4页
China Pharmacist
关键词
长春西汀
自微乳化释药系统
体外释放度
Vinpocetine
Self-microemulsifying drug delivery system
Dissolution in vitro
