摘要
目的 :探讨肝病患者血清载脂蛋白 A1 及 B的变化及临床意义。方法 :测定健康人 10 0例与肝病患者 (乙肝、肝硬化、肝癌 ) 12 9例的血清载脂蛋白 A1 (apo A1 )、载脂蛋白 B(apo B)、胆固醇 (chol)、甘油三脂 (TG)、胆红素及白蛋白的水平。结果 :肝脏病组血清 apo A1及 apo B平均浓度 (0 .84± 0 .6 9) g/ L 及 (0 .86± 0 .16 ) g/ L 明显低于正常对照组 (1.39± 0 .18) g/ L 及 (0 .86± 0 .16 ) g/ L,差异显著 (P <0 .0 5 ) ,其中肝癌组差异非常显著 (P <0 .0 1)。血清 apo A1 与胆红素的浓度上升呈负相关 (r=- 0 .5 43) ,与白蛋白浓度下降呈正相关 (r=0 .5 13)。结论 :血清 apoA1 水平变化可作为反映肝功能和肝病的严重程度的可靠指标。
Objective:To study the change and clinical significance of serum apolipoprotein A1 and B in the patients with liver disease. Methods: The concentrations of apolipoproteins A 1, apolipoprotein B (apo B),cholesterol (chol), triglyceride (TG), bilirubin and albumin were determined in 100 healthy persons,129 patients with liver disease (hepatitis,cirrhosis and cancer of liver).Results: The concentrations of apo A 1 and apo B (0.84±0.69 g/L, 0.56±0.28 g/L) in liver disorder group were significantly lower than these in the control (P<0.05),in hepato cancer the difference was especially (1.39±0.18 g/L, 0.86±0.16 g/L) (P<0.01).There was a negative correlation between apo A 1 and the increase of bilirubin (r=-0.543), while there was a positive correlation between apo A 1 and the decrease of albumin (r=0.513).Conclusion:It is a reliable index that the change of the concentration of apo A 1 in reflecting the liver function and serious degree of liver disese.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2000年第4期308-309,共2页
Journal of China Medical University
