摘要
目的探讨载脂蛋白B(ApoB)水平和高密度脂蛋白/总胆固醇比值(HDL/TC)与非酒精性脂肪性肝病(NAFLD)的相关性。方法收集就诊于山西医科大学第二医院消化内科的NAFLD患者108例(研究组)及健康体检者111名(对照组),对其一般资料及实验室指标等数据进行相关性比较。结果研究组ApoB水平明显高于对照组,而HDL/TC低于对照组,差异有统计学意义(P<0.05);研究组的糖尿病、冠心病发病率均高于对照组,差异有统计学意义(P<0.05);多因素回归分析结果显示,ApoB、HDL/TC、TC、TG、BMI、Cr、尿素、冠心病均与NAFLD相关,其中ApoB相关系数最高。结论 ApoB和HDL/TC均为NAFLD的独立危险因素,在评估NAFLD病变时ApoB水平要优于其他指标,ApoB水平和HDL/TC在评估NAFLD病变时均有一定的临床价值。
Objective To investigate the correlation of apolipoprotein B(ApoB) level and high density lipoprotein/total cholesterol(HDL/TC) with non-alcoholic fatty liver disease(NAFLD). Methods General data and laboratory indicators were collected from 108 NAFLD patients(study group) and 111 healthy physical examinees(control group) in the Second Hospital of Shanxi Medical University, and the correlation of the collected data was compared. ResultsThe ApoB level in study group was significantly higher than that in control group, while HDL/TC was lower than that in control group, the difference was statistically significant(P<0.05);the incidence of diabetes and coronary heart disease in study group was higher than those in control group, and the difference was statistically significant(P<0.05);multivariate regression analysis showed that ApoB, HDL/TC, TC, TG, BMI, Cr, urea, coronary heart disease were related to the formation of NAFLD, of which ApoB correlation coefficient was highest. Conclusion ApoB and HDL/TC are independent risk factors for NAFLD. ApoB level is better than other indicators in the evaluation of NAFLD. It has certain clinical value.
作者
吕佳宏
武希润
LYU Jiahong;WU Xirun(Department of Gastroenterology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《胃肠病学和肝病学杂志》
CAS
2020年第8期865-868,共4页
Chinese Journal of Gastroenterology and Hepatology
