摘要
目的分析抗菌药物临床应用专项整治活动前后医院外科清洁手术预防性抗菌药物的应用并对其合理性做出评价。方法随机选取2011年1-12月专项整治活动前后的200例外科清洁手术患者临床资料为调查对象,以专项治疗时间为界,2011年1-6月为A组,2011年7-12月为B组,各100例,比较两组用药指征、用药时机、药物的选择等指标。结果 B组患者中有56例预防应用抗菌药物,用药指征合理比例为91.07%,高于A组的46.0%,差异有统计学意义(P<0.05);B组中抗菌药物用量合理者比例为100.00%,高于A组的92.00%(P<0.05);B组患者预防应用抗菌药物时机合理比例为75.00%,高于A组的23.00%(P<0.05);B组用药天数(1.5±0.4)d,明显低于A组的(4.5±1.4)d(P<0.05);B组联合用药率为3.57%,低于A组的87.00%(P<0.05);B组选用最多的药物为头孢呋辛、头孢唑林、克林霉素,2～3次/d给药,符合药动学、药效学规律及卫生部关于抗菌药物临床应用品种选择的要求。结论外科清洁手术预防性应用抗菌药物存在不合理现象,通过抗菌药物专项治理,合理率明显提高,抗菌药物专项治理取得了一定成效。
OBJECTIVE To investigate the clinical preventive application of antibiotics in the hospital before and after the special control of antimierobial drugs and to analyze its rationality. METHODS From Jan 2011 to Dec＂ 2011, a total of 200 patients who underwent the clean surgery before and after the special control of antimicrobial drugs were randomly selected as the investigation objects, according to the boundary of special treatment time, the patients undergoing the cleaning surgery from Jan to Jun 2011 were set as group A, the patients from Jul to Dec 2011 were set as the group B, the indicators such as the medication indications , administration timing , and the choice of drug were compared. RESULTS There were 56 cases in the group B who were taken the prophylactic antibiotics, the proportion of reasonable medication indications was 91.07%, higher than 46.0% of the group A, the difference was statistically significant （P〈0.05）. The proportion of the appropriate dosage of antibiotics was 100.0% in the group B, higher than 92.00% in the group A （P〈0.05）. The proportion of the reasonable timing of prophylactic antibiotics was 75.00% in the group B, higher than 23.00% in the group A （P〈0. 05）. The medication duration was （4.5± 1.4） days in the group A, significantly higher than （1.5±0.4）days in the group B （P〈0.05）. The rate of combined use of antibiotics was 3.57% in the group B, lower than 87.0% in the group B （P〈 0. 05）. The most frequently used antibiotics in the group B were cefuroxime, cefazolin sodium, and clindamycin, with the drug administration of twice or three times a day, which was in line with the pharmacokinet- ic and pharmacodynamic rule, and the variety selection requirements on the clinical application of antimicrobial agents by the ministry of health. CONCLUSION There exits the unreasonable prophylactic, use of antibiotics for the clean surgery. The special treatment of antibiotics has made a certain amount of achievement, and the rationality has been improved significantly.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第16期3611-3613,共3页
Chinese Journal of Nosocomiology
关键词
专项治理
清洁手术
抗菌药物
预防性应用
Special treatment
Clean surgery
Antibiotics
Prophylactic use
