摘要
目的 :对剖宫产术预防感染用药进行前瞻性研究 ,为选择合理、经济的给药方案提供依据。方法 :采用 L8(4×2 4 )正交试验设计 ,分为因素和水平各不相同的 8种给药方案 ,2 93例剖宫产随机分组 ,每一方案重复 30次以上 ,监测临床感染性指标。结果 :12 93例剖宫产术 3例术后伤口感染 ,伤口甲级愈合率为 98.6 3% ,术后病率 5 .4 6 % (16 / 2 93) ,院内感染率 3.0 7%。 2对于体温、血象、术后住院日等观察指标 ,在某些因素和水平间存在着显著性差异。结论 :1可采用单品种、短疗程预防感染。常规用药首选头孢唑林 ,体温高或中性粒细胞高者可选用头孢曲松 ,以术前 30分钟给药 ,短疗程为优 ,一般不超过术后 4 8小时。加用灭滴灵二联用药与单一用药无显著性差异 ,考虑到灭滴灵对胎儿 (新生儿 )的不良反应 ,灭滴灵不宜作为剖宫产术预防感染的常规用药。 2正交试验可作为合理使用抗生素的筛选方法。
Objective:A prospective study on administrating antibiotics for preventing postoperative infections of cesarean section was carried out in order to provide a basis for selection of administration scheme Methods:By using L 8(4×2 4) orthoganal table design,8 schemes with different administration factors and levels were designed 293 cases cesarean section were randomly divided into groups and each group received on scheme with thirty five repetitions Clinical indices for infection were odserved Results:(1)No postoperative infectious complications occurred in all groups All wounds healed in grade A (2) There were significant differences between some factors or levels in patients temperature and hemogram Conclusion:(1)For preventing infection,a scheme of single drug and short course may be adopted As a routime,cefezolin is the drug of choice and in case of neutrocytosis,rocephin may be given,in case of leucocytosis,cefezolin and metronidazole may be given together,preventing infections (2)Orthogonal table design is a good method for optimizing drug administration scheme on drug utilization and phamacoeconomics study
出处
《广西医学》
CAS
2002年第4期466-468,共3页
Guangxi Medical Journal
