摘要
目的：观察吗啡依赖大鼠及戒断大鼠垂体远侧部促肾上腺皮质激素（ＡＣＴＨ）细胞和甲状腺刺激激素（ＴＳＨ）细胞的变化。方法：皮下规律注射吗啡建立大鼠吗啡依赖模型，戒断后造成戒断模型并用免疫组织化学和图像分析方法检测吗啡依赖及戒断后大鼠垂体远侧部ＡＣＴＨ细胞和ＴＳＨ细胞的变化。结果：吗啡依赖大鼠ＡＣＴＨ细胞和ＴＳＨ细胞免疫反应减弱（Ｐ＜０．０１），短期戒断后这些改变仍持续存在。结论：吗啡可导致大鼠脑垂体分泌功能紊乱，且短期戒断后未能完全恢复。
AIM: To investigate the change of adrenocorticotropic hormone (ACTH) cells and thyroid- stimulating hormone(wn) cells of pars distalls of pituitary gland of morphine dependent dependent rats and its restoration after withdrawal. METHODS: Morphine dependent model of male rats was made by subcutaneous injection of mor- phine and the adstinent model was made after withdrawal. Changes of ACTH cells and TSH cells of pars distails of pituitary gland were detected by immunohistochemistoy survey and image analysis. RESULTS: The intensity of positive staining and the numerical density of ACTH and TSH immunoreactive cells were weakened (P＜ 0.01), after withdrawal from morphine for a short time the changes would exist continuously. CONCLUSION: Morphine may give rise to disorder of endocrine of pituitary gland of male rats, which may incompletely restore after withdrawal for a short time.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2000年第4期354-356,共3页
Chinese Journal of Pathophysiology
关键词
吗啡依赖
促甲状腺素
ACTH
TSH
Morphine dependence
Immunohistochemistry
Adrenocroticotropic hormone
Thyrotropin
