摘要
目的 :探讨氧化苦参碱对中枢神经系统的影响。方法 :采用行为药理学方法观察并测定氧化苦参碱对阈剂量和阈下剂量戊巴比妥纳催眠作用的影响 ,对小鼠外观活动和自发活动的影响及对戊四氮和最大电惊厥的影响。结果 :ip氧化苦参碱 5 0、10 0、2 0 0mg/kg小鼠自发活动抑制率分别为 5 4 3 %、43 0 %、71 0 % ,戊巴比妥钠入睡时间分别缩短 32 9%、32 9%、43 8% ,而睡眠时间分别延长 2 0 9 8%、42 1 2 %、6 86 8% ,并能明显加强阈下剂量戊巴比妥钠的催眠作用。氧化苦参碱 2 0 0、40 0mg/kgip均不能对抗戊四氮和最大电休克引起的惊厥。结论 :氧化苦参碱具有镇静。
Objective: To find out the influence of oxymartirine on central nervous system. Methods: By observeing the changes of spontaneous activity, by measuring the changes of hypnotic action induced with pentobarbital in threshold or subthreshold doses and by examinnig the changes of convulsion caused by pentylenetetrazole and maximal electric shock, the action of oxymartrine on central nervous system would be found out Results: Compared with control group, in experimental group mice, being given intraperitoneally oxymartrine 50、100、200 mg/kg, inhibitory rates of spontaneous activity were 54.3%、 43.0% and 71.0%, the latent period of falling asleep induced by pentobarbital administration was shortened by 32.9%、32.9%、43.8% and the sustained period of sleep was lengthenedby 209.8%、421.2% and 686.8% respectively and hypnotic action subsequent to administration of pentobarbital in a subthreshold dose was greatly enhanced. Oxymartrine 200 mg/kg and 400 mg/kg could not antagonize the convulsion caused by pentylenetetrazole and maximal electrical shock. Conclusion: Oxymartrine possesses inhibitory effects on central nervous system.
出处
《宁夏医学院学报》
2000年第3期157-158,162,共3页
Journal of Ningxia Medical College
