摘要
本研究分A、B两组对33例重症病毒性心肌炎进行治疗。A组18例用肾上腺皮质激素加中药治疗;B组15例用肾上腺皮质激素加干扰素治疗。对比两组治疗结果:(1)在缓解窦房阻滞、房室传导阻滞、室性心动过速及急性泵衰竭等临床症状以及心电图的改善方面效果类同。(2)不论A组或B组在治疗后其OKT_3、OKT_4、OKT_8、OKT_4/OKT_8以及NK细胞活性均较治疗前升高,P值均<0.05或<0.01,有显著性差异,但A、B二组间无差异。说明中药治疗的效果与价格昂贵的干扰素相似,且无副作用。
33 patients divided into 2 groups for treatment. Group A (18 cases) early use of adrenal cortico-steroid treatment in combination with traditional Chinese medicine, group B (15 cases) early use of adrenal cortico-steroid treatment is combination with interferon, then compared the therapeu-tic effects of these 2 groups. The results showed that, in these 2 groups, the sinus-atrial block,atrial veotricular block, ventricular tachycardia, acute pump failure as well as the EKG changes were relieved and improved to the same degree. In group A, after therapy the parameters of OKT_3 (%)was elevated from 51±15.22 to 55.23±8.53; OKT_4(%) was elevated from 30.06±11.47 to 47.32±10.87; ratio of OKT_4/OKT_8 was elevated from 1.11 to 1.53; all of their P values were<0.01. NK cell activity was elevated from 8.36±3.75 to 13.08±5.77, P value<0.05. In group B, the parame-ters of OKT_3 (%) was elevated from 50.91±8.12 to 56.75±8.29: OKT_4(%) was elevated from 32.55±6.78 to 45.13±10.85: ratio of OKT_4/OKT_8 was elevated from 1.00±0.21 to 1.37±0.16: P value <0.05, <0.05 and <0.01 respectively. NK cell activity (%) was elevated from 8.20±3.08 to 14.03±4.89, P value also<0.01. Hence, not only in group A but also in group B, after therapy, theparameters of OKT_(3,4,8,) OKT_4/OKT_8 and NK cell activity(%)were all improved. But there was no significant statistical difference between group A and B. It suggested that, traditional Chinese medicine therapy might be used instead of expensive interferon therapy with no side effect.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1992年第7期398-401,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
心肌炎
中西医结合
savere type viral myocarditis
adrenal corticosteroid
interferon
lymphocyte
monoclonal antibody
Coxakie B virus
Natural Killer cell
