摘要
氧化苦参碱腹腔注射可明显抑制大鼠被动皮肤过敏反应(PCA),管内给药可显著抑制亲同种细胞抗体介导的肥大细胞脱颗粒;对反相皮肤过敏反应(RCA),Arthus反应及绵羊红细胞(SRB C)诱导的迟发型过敏反应(DTH)亦有显著抑制作用。
Oxymatrine was extracted from Radix sophorae flavescentis. Oxymatrine (60 mg/kg ip) significa-ntly inhibited 48 h homologous passive cutaneous anaphylaxis (PCA) in rats. At concetration of 125,625 μmol/L, Oxymatrine decreased the degranulation rate of mast cells mediated by homocytotropic antibody. It showed a marked suppressive effect on reversed cutaneous anaphylaxis (RCA) and Arthus type reactivity in rats. It also inhibited delayed type hypersensitivity (DTH) to sheep red blood cells (SRBC) in normal mice.
出处
《北京医科大学学报》
CSCD
1991年第6期445-447,共3页
Journal of Peking University(Health Sciences)
关键词
氧化苦参碱
过敏反应
皮肤
Oxymatrine
Passive cutaneous anaphylaxis
Reversed cutaneous anaphylaxis
Mast cells degranulation
Arthus reaction
Delayed type hypersensitivity
