摘要
目的可降解高分子以及羟基磷灰石等活性生物陶瓷构建的组织工程支架机械性能很差,限制了其在承重骨方面的应用。氧化锆陶瓷材料因其优越的生物相容性和力学性能成为了最有潜力的骨组织工程支架材料。文中通过对模板成型法的探索,制备三维联通的氧化锆骨组织工程支架。方法用多孔聚氨酯为模板,以高固含量低黏度纳米氧化锆悬浮液为起始溶液,制备氧化锆多孔支架;采用XRD,SEM对样品进行表征分析。结果 XRD图谱显示在1100～1350℃这个煅烧温度范围内,纳米氧化锆支架的晶型无改变,保持室温下机械性能最好的四方相,平均粒径170 nm。成型的支架孔隙率高,内部三维联通,与人骨结构相似,支架的微观结构随模板的变化而改变。结论聚氨酯模板法制备的纳米氧化锆支架具良好的三维连通性,类似人的骨松质结构。可通过对聚氨酯模板孔径的调节达到对纳米氧化锆骨组织工程支架的结构控制,从而实现对三维连通支架的孔隙大小及孔隙率的调节。
Objective In tissue engineering, porous scaffolds made by biodegradable polymer and biologically active hydroxyapatite ceramic exhibit poor mechanical properties, which limit their application in load-bearing bone. Porous zirconia has been regarded as a potential candidate for bone tissue engineering due to its good biocompatibility and high mechanical strength. This study is to fabricate ZrO2 scaffold with interconnected pores for bone tissue engineering by a polymeric sponge replica method. Methods ZrO2 slurry （65wt%） was coated on the polyurethane （PU） sponge. Then the green body was slowly heated to 1350 ~C. Eventually the porous nano-ZrO2 scaffold was characterized by X-ray diffraction （XRD） and scan emission microscopy （SEM）. Results The XRD spectrum showed that ZrO2 scaffold remained a tetragonal phase in the temperature range of 1100 - 1350 ℃ and the average diameter was 170 nm. The ZrO2 scaffolds with high porosity and interconnected pores just like human bones were controllable by changing different PU templates. Conclusion The interconnected ZrO2 scaffolds fabricated by the polymeric sponge replica method have the same structure as trabecular bone.
出处
《医学研究生学报》
CAS
北大核心
2012年第6期635-640,共6页
Journal of Medical Postgraduates
关键词
氧化锆
支架
成型方法
骨组织工程
Zirconia
Scaffold
Preparation
Bone tissue engineering
