摘要
在丙酮溶液中 ,于 Et3 N存在下使 2 -取代 - 5-氟 - 4 -嘧啶酮与酰氯反应 ,合成了 1 4个未见文献报道的 2 -取代 - 3- N-酰基 - 5-氟 - 4 -嘧啶酮类化合物 ,它们的结构经 IR,1H NMR,元素分析或 MS确定。其中有些化合物具有一定的抗肿瘤活性。
Fourteen new 2-substituted-3-acyl-5-fluoro-4-pyrimidone compounds were prepared by the reaction of 2-substituted-5-fluoro-3H-4-pyrimidones with acyl chlorides in acetone in the presence of Et_3N. Their structures were confirmed by IR, 1H NMR and elementary analysis or MS. The preliminary antitumor tests showed that some of them exhibited certain activities.
出处
《合成化学》
CAS
CSCD
2000年第3期248-251,共4页
Chinese Journal of Synthetic Chemistry
