摘要
目的了解孕母与新生儿维生素D水平及相关的影响因素。方法采用酶联免疫法检测499名30～37周孕龄的母亲和配对新生儿脐血的血清25-羟维生素D[25-（OH）D]浓度，并采用直线相关和回归及二分类logistic回归进行关联性和相关影响因素的横断面分析。结果孕母血清25-（OH）D水平为（33．0±13．4）nmol／L，新生儿为（31．0±12．5）nmol／L，分别有88．8％的母亲及91．2％的新生儿血清25-（OH）D水平〈50nmol／L。孕母及新生儿25-（OH）D水平存在明显的季节差异（均P=0．000），春季最低，98．6％的孕母和99．3％的新生儿25-（OH）D水平〈50nmol／L；秋季最高，但仍有64．0％的孕母及75．0％的新生儿〈50nmol／L。除季节外，孕期钙维生素D合剂补充和蛋类摄入≥600g／周有利于提高孕母维生素D水平[25-（OH）D≥50nmol／L]（OR值分别为2．3、3．4，均P=0．000）。孕母-新生儿25-（OH）D水平呈正相关（r=0．45，P=0．000），当孕母25-（OH）D水平≤25nmol／L时，则两者相关性无统计学意义（P〉0．05）。结论孕母及其新生儿的维生素D水平普遍较低，以春季最低；含维生素D制剂及富含维生素D食物的摄人可改善维生素D营养状况；孕母-新生儿25-（OH）D水平呈中度正相关，当孕母25-（OH）D水平≤25nmol／L时，则两者相关性不明显。
Objective To determine the relationship between maternal and neonatal vitamin D status and related factors. Method Serum 25-（ OH ） D levels were measured by ELISA in 499 pregnant women at 30-37 weeks gestation and in cord blood of their infants born at term （37-42 wk gestation ） in Southeastern China at 28.9° N latitude . One-way analysis of variance （ ANOVA ） was used to explore maternal and neonatal vitamin D levels by season. Pearson linear and linear regression of partial correlation was used to analyze the relationship between maternal and neonatal 25- （OH） D levels. The multiple factors related to maternal vitamin D status was assessed by binary logistic regression. Result The levels of serum 25-（OH） D were （33.0 ± 13.4） nmol/L in mothers and （31.0 ± 12. 5 ） nmol/L in their newborns. Serum 25-（OH） D 〈 50 nmol/L was shown in 88.8% of mothers and 91.2% of their neonates. Both maternal and neonatal 25-（ OH ） D levels varied with season （ Ps = 0. 000 ）. Vitamin D level was the lowest in spring, with the 25-（OH） D concentration 〈 50 nmol/L in 98.6% of mothers and 99. 3% of their neonates. The highest vitamin D level was presented in fall, but there were still 64. 0% of mothers and 75.0% of neonates with 25- （OH）D 〈50 nmol/L. Except for season, calcium-vitamin D supplement and intake of egg I〉600 g per week during pregnancy benefited to improve maternal vitamin D level [25-（OH） D 〉150 nmol/Ll [ OR = 2. 3（95%CI：1.0, 5.3）, 3.4（95%CI：1.2, 9. 9） respectivelyl. There was a positive correlation between maternal and neonatal 25- （ OH ） D measures in the sample as a whole （ r = 0. 45, P = 0. 000, N = 499 ）, the correlation was of no statistical significance when maternal serum 25-（OH） D was 〈~25 nmoL/L. Conclusion Hypovitaminosis D was common in late pregnant mothers and their newborns in southeastern China, especially in spring. Vitamin D supplement and intake of vitamin D-rich food were beneficial to improvement of maternal vitamin D level. There was a moderate and positive correlation between maternal and neonatal 25-（ OH ）D concentrations in this population. The correlation was lost when maternal serum 25-（OH） D ≤ 25 nmol/L.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
2012年第7期498-503,共6页
Chinese Journal of Pediatrics
基金
国家十一五科技支撑计划项目（2009BA180800）
国家自然科学基金资助项目（30671773）
关键词
维生素D
孕妇
胎血
婴儿
新生
Vitamin D
Pregnant women
Fetal blood
Infant, newborn
