4R. zuin, A palamideese, R Negrin, el al. High - Dose N - acetylcysteine in COPD exacerbations [J]. Clin Drug Invest, 2005, 25 (6) : 401 - 408.
5Weiss SJ. Tissue destrution by neutrophils [J]. N Engl J Meal, 1989, 320 (6): 365 - 76.
6Heffner JE, Repine JE. Pulmonary strategies of mltioxidant defense[ J ].Am RevRespir Dis, 1989, 140 (2): 53- 54.
7Dekhuijzen PN. Autioxidant properties of N - acewlylcysteine: their relevance in relation to chronic obstructive pulmonary disease [J]. Eur Respir J, 2004, 23 (4): 629 - 36.
8De benedetto F, Aceto A, Dragani B, el al. Long- term oral N - acetylcystein reduce exhaled hydrogen peroxide in stable COPD [ J ]. Palm Phamacol Ther, 2005, 18 (1): 41-7.
9Pinkus R, Weiner LM, Daniel V. Role of oxidants and antioxi - dants in Ihe induction of AP - 1, NF - kB, and glutafllione s - transferase gene expression [J]. J Biol Chem, 1996, 271 (23): 13422-9.
10Malo O, Sauleda J, Busquets X, d al. Systemic inflammation during exacerbations of chronic obstructive Pulmonary thsemse [J]. Arch Bronconeumol, 2002, 38 (4): 172 -6.