摘要
目的通过观察补肺化纤汤治疗慢性阻塞性肺疾病大鼠的肺功能、TGF-β1及胶原蛋白Ⅲ含量变化,探讨慢性阻塞性肺疾病的发病机制,为补肺化纤汤的治疗作用提供理论依据。方法雄性SD大鼠随机分成正常对照组(A组)、补肺化纤汤治疗组(B组)、N-乙酰半胱氨酸组(C组),B组按25g/kg予补肺化纤汤,C组按80mg/kg予N-乙酰半胱氨酸灌胃。结果 B组较C组肺功能有改善(P<0.05)。C组肺组织胶原蛋白Ⅲ含量高于B组(P<0.01)。血清中,B组和C组TGF-β1含量均高于正常对照组,但差异无统计学意义(P>0.05)。结论补肺化纤汤具有抗氧化性损伤作用,可以改善已损伤的肺功能。
Objective To observe the effect of Bufeihuaxian decoction on the pulmonary function,the changes of TGF-β1 and collagen Ⅲ content in rats with chronic obstructive pulmonary disease（COPD） caused by smoking in order to investigate the pathogenesis of COPD and to privide theoretical basis for the therapeutic effect of Bufeihuaxian decoction.Methods The male Sprague Dawley（SD） rats were randomly divided into three groups：normal control group（group A）,Bufeihuaxian decoction treatment group（group B）,N-acetyl cysteine model group（group C）.The rats in group B were given with Bufeihuaxian decoction at 25g/kg by gavage,and the rats in group C were given with N-acetyl cysteine at 80mg /kg by gavage.Results The group B was superior to group C in the improvement of pulmonary function of the rats（P0.05）.The levels of collagen Ⅲ in group C were significantly higher than those in group B（P0.01）.The serum content of TGF-β1 in group B and group C was higher than that in group A,however,there was no significant difference among them（P0.05）.Conclusion Bufeihuaxian decoction has the effect in resisting oxidative damage,which can improve the impaired pulmonary function.
出处
《河北医药》
CAS
2011年第6期821-823,共3页
Hebei Medical Journal
关键词
肺疾病
慢性阻塞性
补肺化纤汤
N-乙酰半胱氨酸
抗氧化
pulmonary disease
chronic obstructive
Bufeihuaxian decoction
N-acetylcysteine
antioxidant
