2Knight K R,Burdon J G,Cook L,et al.The protainase antiproteinase theory of emphysema;a speculative analysis of recent advance into the pathogenesis of emphysema[J].Respirology,1997,2:91-95.
5Knight KR,Burdon JG,Cook L,et al.The protainaseantiproteinase theory of emphysema:a speculative analysis of recent advance into the pathogenesis of emphysema.Respirology,1997,2:91-95.
6Terry CM.Effect of tumor necrosis factor alpha and interleukinlalpha on teme oxygenase-1 expression in human endothelial cells.Am J Physiol,1998,274(3 Pt 2):H883-H891.
7Halliwell B.Antioxidants in human health and disease.Ann Re Nutr,1996,16:33-50.
9Tsoumakidou M,Tzanakis N,Chrysofakis G,et al.FCCP Nitrosative Stress,Heme Oxygenase-1 Expression and Airway Inflammation During Severe Exacerbations of COPD.Chest,2005,127:1911-1918.
10Farkhutdinov UK,Abdrakhmannova LM,Farkhurdinov RR.Effects of halitherapy on free radical oxidation inpatients with chtonic bronchiris.Klin Med,2000,78:37-40.
4Global Initiative for Chronic Obstructive Lung Disease.Global strategy for the diagnosis,management,and prevention of chronic obstructive pulmonary disease:GOLD executive summary.Am J Respir Crit Care Med,2007,176 (6):532-555.
5Repine JE,Bast A,Lankhorst I,et al.Oxidative stress in chronic obstructive pulmonary disease.Am J Respir Crit Care Med,1997,156(32):341-357.
6Macnee W,Rahman I.Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease.Am J Respir Crit Care Med,1999,160(5):S58-S65.
7Pela R,Calcagni AM,Subiaco S,et al.N-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD.Respir,1999,66 (6):495-500.
8De Flora S,Grassi C,Carati L.Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with longterm N-acetylcysteine treatment.EurRespir J,1997,10(7):1535-1541.
9Decramer M,Rutten-van Molken M,Dekhuijzen PN,et al.Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study,BRONCUS):a randomized placebo-controlled trial.Lancet,2005,365(9470):1552-1560.
10Knight KR,Burdon JG,Cook L,et al.The proteinase-antiproteinase theory of emphysema:a speculative analysis of recent advances into the pathogenesis of emphysema.Respir,1997,2(2):91-95.