摘要
目的观察持续性心房颤动(简称房颤)导管消融术前后血浆脑钠肽(BNP)及血管紧张素Ⅱ水平(AngⅡ)的变化。方法随机选取48例正常健康人作为对照组,测定其血浆BNP及AngⅡ水平,测定48例持续性房颤且无器质性心脏病患者导管消融术前及术后120 d的血浆BNP和AngⅡ水平。结果导管消融后4个月,8例(17%)患者复发房颤。消融术前,房颤组的血浆BNP及AngⅡ水平高于对照组,差异有统计学意义(P<0.05);导管消融后4个月房颤组血浆BNP及AngⅡ水平与术前比较下降,差异有统计学意义(P<0.05),而与对照组比较,无显著性差异(P>0.05)。结论持续性房颤导管消融前血浆BNP及AngⅡ升高,消融术后均下降。
Objective To investigate the changes of plasma brain natriuretic peptide（BNP） and angiotensin Ⅱ（Ang Ⅱ） levels before and after catheter ablation in patients with persistent atrial fibrillation（AF）.Methods 48 health persons with normal sinus rhythm were chosen as control group and plasma BNP and Ang Ⅱ levels were measured in them,whereas Plasma BNP and Ang Ⅱ levels were measured before and 120 days after catheter ablation in 48 patients with persistent atrial fibrillation without structural heart disease（AF group）.Results Exceeding to 4-month follow-up after catheter ablation,atrial fibrillation recurred in 8（17%） patients.Before catheter ablation,plasma BNP and Ang Ⅱ levels in AF group were significantly higher than those in control group（P0.05）.Compared to that before catheter ablation,plasma BNP and Ang Ⅱ levels were significantly decreased in AF group after catheter ablation（P0.05）,whereas there was no obvious difference about them between AF group and control group（P0.05）.Conclusion In patients with persistent AF without structural heart disease,plasma BNP and Ang Ⅱ levels were increased before catheter ablation,whereas after catheter ablation,they were decreased.
出处
《安徽医药》
CAS
2012年第3期331-333,共3页
Anhui Medical and Pharmaceutical Journal
关键词
心房颤动
导管消融术
利尿肽
脑
血管紧张素Ⅱ
atrial fibrillation
catheter ablation
natriuretic peptide
brain
angiotensin Ⅱ
