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GRACE危险评分与N-末端脑钠肽前体在非ST段抬高急性冠脉综合征患者中的临床研究 被引量：8

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摘要 目的探讨非ST段抬高急性冠脉综合征(NSTE-ACS)患者血浆N-末端脑钠肽前体(NT-proB-NP)水平与全球急性冠状动脉事件注册(GRACE)评分的相关性及其与临床预后的关系。方法入选136例我院住院的NSTE-ACS患者,其中不稳定型心绞痛(UA)89例,非ST段抬高心肌梗死(NSTEMI)47例,对其进行GRACE危险评分并进行危险分层,采用免疫荧光法测定血浆NT-ProBNP数值,分析患者血浆NT-ProBNP水平与GRACE危险积分不同层次之间的相关性,并随访所有患者主要心血管事件发生情况。结果血浆NT-ProBNP水平与GRACE危险积分分值呈正相关关系(r=0.72,P<0.05);随着GRACE评分值越高,血浆NT-ProBNP浓度水平亦增高,随访期主要心血管事件发生率也随之增高(P<0.05)。结论 NT-ProBNP水平越高,GRACE积分越高,在NSTE-ACS患者中,联合运用GRACE危险积分与NT-ProBNP水平检测,在对其进行早期危险分层、评估预后方面有重要临床价值。
作者 葛璘 陈湘
机构地区 北京航天总医院心内科
出处 《实用心脑肺血管病杂志》 2012年第10期1610-1611,共2页 Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词 急性冠脉综合征 GRACE危险评分 脑利尿肽
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献6

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同被引文献85

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引证文献8

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实用心脑肺血管病杂志
2012年 第10期

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