摘要
目的:观察冠心病患者血浆中单核细胞趋化蛋白-1(MCP-1)的浓度,探讨其诊断冠心病的意义及临床价值。方法:将122例患者分为非冠心病组(30例)、稳定型心绞痛组(32例)、不稳定型心绞痛组(27例)和急性心肌梗死组(33例),应用酶联免疫吸附法检测患者血浆中MCP-1、组织因子(TF)的浓度。结果:①血浆中MCP-1、TF的浓度均为:非冠心病组<稳定型心绞痛组<不稳定型心绞痛组<急性心肌梗死组(均P<0.05)。②血浆中MCP-1的浓度与患者的性别、吸烟、冠心病家族史、高血压和糖尿病、TG、HDL-C、尿素氮、肌酐无明显相关性(均P>0.05),与年龄、体质指数、TC、LDL-C、尿酸、心肌肌钙蛋白I、肌酸激酶同工酶、TF呈正相关性(均P<0.05)。③以血浆中MCP-1的浓度作为诊断急性冠状动脉综合征的指标,ROC曲线分析结果显示MCP-1的诊断价值较大,曲线下面积0.939(P<0.05),最佳临界值为320.5ng/L,其特异度和灵敏度分别是86.7%和88.0%。结论:血浆中MCP-1在判断冠状动脉粥样硬化斑块易损性方面有一定的临床意义,可能是冠心病的一个独立危险因素,可作为诊断急性冠状动脉综合征的理想指标。
Objective：To investigate the significance and clinical value of plasma monocyte chemotactic protein-1（MCP-1） in diagnosis of coronary heart disease（CHD） by observation of the concentrations of plasma MCP-1 in patients with CHD.Method：One hundred and twenty-two patients were divided into Non-CHD group（control group,n=30）,SAP group（n=32）,UAP group（n=27） and AMI group（n=33）.In all these groups,the concentrations of plasma MCP-1 and tissue factor（TF） in the patients were detected by ELLSA.Result：①The concentrations of plasma MCP-1 and TF were： control group〈SAP group〈UAP group〈AMI group（all P〈0.05）.②The concentrations of plasma MCP-1 was not correlated with gender,smoking status,history of CHD,hypertension,diabetes,TG,HDL-C,urea nitrogen and creatinine（all P〈0.05）,but it was positively correlated with age,BMI,TC,LDL-C,uric acid,cTnI,CK-MB and TF（all P〈0.05）.③Using concentration of plasma MCP-1 as a diagnostic indicator of acute coronary syndrome,ROC curve analysis showed that MCP-1 had diagnostic value,the area under ROC curve of MCP-1 was 0.939（P〈0.05）,the best critical concentration of plasma MCP-1 was 320.5 ng/L,the specificity and sensitivity were 86.7% and 88.0%.Conclusion：Plasma MCP-1 may have clinical significance in reflecting the vulnerability of atherosclerotic plaque,it may be an independent risk factor of CHD and a good indicator in diagnosis of acute coronary syndrome.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2012年第5期367-370,共4页
Journal of Clinical Cardiology
