摘要
目的:观察天香丹颗粒治疗冠心病心绞痛患者的疗效,并探讨其作用机理。方法:60例气虚血瘀、痰瘀交阻型冠心病心绞痛患者随机分为两组;天香丹治疗组33例,心可舒对照组27例。服用天香丹颗粒或心可舒4周后,观察患者临床症状、心电图的变化及血清中可溶性细胞间黏附分子-1(sICAM-1)和可溶性血管细胞黏附分子-1(sVCAM-1)的水平变化。结果:天香丹组胸闷、胸隐痛时作、气短乏力等症状改善明显优于心可舒组;天香丹组心电图有效率(63.64%)高于心可舒组(37.04%)(P<0.05);天香丹组血清sICAM-1s、VCAM-1水平较心可舒组下降更明显(P<0.01)。结论:天香丹颗粒可改善冠心病心绞痛患者临床症状及心电图表现,其机制可能与并有抑制黏附分子的表达,改善内皮功能有关。
Objective： To assess the efficacy of ＂Tianxiangdan Granule＂（TXDG） in angina pectoris following coronary heart disease（CHD）, and to explore the mechanism of it. Methods： 60 CHD patients with the syndrome type of qi deficiency combined with blood stasis and phlegm retention were randomly assigned to treatment group（n = 33） and control group（n = 27）, taking either TXDG or Xinkeshu Tablet（XKST） for four weeks. The changes of main symptoms, cardiogram, semm soluble intercellular adhesion molecule-1（sICAM-1） and serum soluble vascular cell adhesion moleculc-1（sVCAM-1） were observed. Results： Compared with XKST, TXDG improved the main symptoms and decreased the levels of semm sICAM-1 and sVCAM-1 more effectively; the effective rate of cardiogram in treatment group was 63.64%, and in control group was 37.04% （P〈0.05）. Conclusion： TXDG can improve clinical symptoms, cardiogram changes in patients with CHD, possibly by restraining the expression of serum slCAM-1 and sVCAM-1, and improving the endothelial function.
出处
《上海中医药大学学报》
CAS
2006年第2期29-31,共3页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
新疆自治区科学研究与技术开发计划基金项目(960103001)
上海市科委资助西部合作项目(044058034)
关键词
冠心病心绞痛
天香丹颗粒
可溶性细胞间黏附分子-1
可溶性血管细胞黏附分子-l
心电图
Coronary angina pectoris
＂Tianxiangdan Granule＂
serum soluble intercellular adhesion molecule-1
serum soluble vascular cell adhesion molecule-1
cardiogram
clinical study
