摘要
目的 探讨女工二硫化碳 (CS2 )接触水平与胚胎早期发育障碍之间的剂量—反应关系。方法 前瞻观察欲生育女工妊娠所需的月经周期数 ;收集每个月经周期胚胎植入期尿样 ,检测绒毛膜促性腺激素含量 ;监测女工作业地点CS2 浓度。结果 ①接触组女工各月经周期妊娠机率低于对照组 ,时间妊娠率随接触水平 (孕时CS2 接触浓度乘以CS2 接触工龄 )升高而降低 :妊娠率 =0 70 3 3 -0 0 0 15×接触水平 ( χ2 =64 71,P =0 .0 0 0 ;r =-0 .979,P =0 .0 0 0 ) ;②检测 3 4 0个月经周期尿样的早早孕丢失率 ,接触组明显高于对照组 ,且随接触水平升高而增加 :丢失率 =0 4717+0 0 0 2 8×接触水平 ( χ2 =2 5 .5 9,P =0 .0 0 1,r =0 .977,P =0 0 0 0 )。结论 随着接触水平的增高 ,早早孕丢失率明显增加 ;每个月经周期妊娠率降低 ,均呈现出明显的剂量—反应关系 ,表明CS2
Objective To study the dose response relationships between carbon disulphide (CS 2) exposure levels (EL, the concentrations of CS 2 multiplied by years of exposure when pregnancy was identified) and the rates of time to pregnancy, or and the rates of very early pregnancy loss in female workers. Methods Following up how many menstruation cycles needed for getting a clinically identified pregnancy for each woman who attempted to have a baby, collecting daily urine samples at implantation for measuring the level of human chorionic gonadotropin while menstruations and clinical pregnancy was traced, and monitoring the concentrations of CS 2 in her working site.Results When the EL went up, the rates of time to pregnancy(RP) went down. The relation between RP for first six menstrual cycles and the EL was RP=0.703 3-0.001 5 EL( χ 2=64.71, P=0.000; r=-0.979,P=0.000 ). When the EL rised, the rates of very early pregnancy loss (RL) became higher. The relation between RL and EL was RL=0.471 7+0.002 8 EL ( χ 2=25.59, P=0.001; r=0.977, P=0.000 ).Conclusion It showed that there were dose response relationships between EL and RP or/and RL, and that along with the rising of EL, accumulation toxicity on early embryoes development appeared.
出处
《中国职业医学》
CAS
2000年第2期13-15,共3页
China Occupational Medicine
关键词
生殖损伤
二硫化碳
剂量-反应关系
胚胎损伤
reproductive damage, very early pregnancy loss, carbon disulphide, dose response relationship, accumulation toxicity
