摘要
目的 :探讨 C- erb B- 2癌基因蛋白在乳腺肿瘤中的表达情况及临床意义。方法 :应用免疫组化 SP法 ,对 12 6例乳腺良恶性肿瘤进行 C- erb B- 2癌基因蛋白检测 ,对其中 97例乳腺癌进行雌激素受体 (ER)和孕激素受体 (PR)检测。结果 :C- erb B- 2蛋白阳性表达的细胞主要为癌细胞。C- erb B- 2蛋白在导管内癌、Paget's病及浸润性导管癌中呈高表达 ,在浸润性小叶癌中均呈阴性表达。C- erb B- 2蛋白呈阴性表达又无淋巴结转移者 ,10 a生存率较高。结论 :C- erb B- 2蛋白表达既可用于鉴别乳腺良恶性病变和乳腺癌的早期诊断 。
Objective:To study the expression and significance of C erbB 2 protein in breast neoplasm.Methods:126 cases of benign and malignant breast neoplasm were examined by immunohisto chemical S P method.Among them,97 cases of breast carcinomas were examined for estrogen and progesterone receptor status.Results:The most positive cell of C erbB 2 were cancer cells.There was a higher expression of C erbB 2 in intraductal carcinoma,Paget's dissease and infiltrating duct cancinoma.All were negative in infiltrating lobular carcinoma.Those with C erbB 2 protein negative and lymph-node negative had higher 10 year survival rate.Conclusion:The expression of C erbB 2 protein was used either to distinguish benign or malignant tumor and early diagnosis of breast carcinoma, or to be a indicator to predict the prognosis of breast carcinoma.
出处
《肿瘤研究与临床》
CAS
2000年第2期92-94,共3页
Cancer Research and Clinic
关键词
乳腺肿瘤
癌基因
免疫组织化学
雌激素受体
Breast neoplasm
Oncogenej Immunohistochemistry
Estrogen receptor
Progesterone receptor
