摘要
目的:研究原癌基因c-erbB-2和增殖细胞核抗原(PCNA)在乳腺癌中的表达情况及其与ER、PR表达的相关性,探讨其与乳腺癌发生、发展的内在联系。方法:选取我院2003年手术治疗的乳腺癌患者63例,采用免疫组织化学染色法,对乳腺癌癌组织进行c-erbB-2、PCNA检测,并与传统ER、PR指标及临床病理特点作相关性分析。结果:63例乳癌中均见有PCNA表达(100%),c-erbB-2表达者36例(57.1%);ER阳性35例(55.6%),PR阳性30例(47.6%)。PCNA、c-erbB-2的阳性表达与患者绝经与否及病理的组织学分级无明显相关性,而与淋巴结的转移呈显著正相关;PCNA的表达与ER、PR表达均呈显著负相关,c-erbB-2的表达与ER表达呈负相关。结论:在乳癌恶性程度的判断上,ER、PR的表达和PCNA、c-erbB-2的表达之间有明显的互补性,在使用传统指标判断乳癌预后和制订术后治疗方案的同时,进一步检测PCNA和c-erbB-2的表达,特别是PCNA的表达,具有重要的参考价值。
Objective To investigate the relationships between the expression of c erbB 2, proliferating cell nuclear antigen (PCNA) and estrogen receptor (EP), progesterone receptor (PR) in breast cancer , and to discuss the relationship between c erbB 2, PCNA and the prognosis of breast cancer. Methods Paraffin embedded tissue sections obtained from 63 selective breast carcinomas were evaluated immunohistochemically for c erbB 2 oncoprotein , PCNA, ER and PR. The relations between these markers and the clinicopathologic characteristics were evaluated. Results All 63 cases (100%) expressed PCNA and 36 cases (57.1%) expressed c erbB 2. ER and PR were expressed in 35 and 30 cases respectively. The expression of PCNA and c erbB 2 were significantly correlated with the lymph node metastasis, but had no relationship with the menopause and the pathological classify of the cancer. The over expression of PCNA was negatively correlated with the expression of ER and PR. The over expression of c erbB 2 was negatively correlated with ER. Conclusion While using the traditional markers to arrange the post operation therapeutic program and predict the prognosis of breast cancer, taking an ulterior step to evaluate the expression of PCNA and c erbB 2, especially PCNA, will be more valuable.
出处
《实用医学杂志》
CAS
2005年第2期136-138,共3页
The Journal of Practical Medicine
